Gaurdant blood test

[crony]

My test revealed a mutation called Andorogen receptor Amplification. This explains how it went from my L2 to my rib, femurs, and lower back. My doctor did not say why or how this information

will benefit my treatment, so I really don't get it. Just waiting g for approval to start PLUVITCO. Any one out there have any thoughts on this? Thank you all. Jim

[Tall_Allen]

ALL advanced Prostate Cancer patients eventually have AR amplification. It's one of the ways in which the cancer becomes castration resistant, while becoming ever more sensitive to even the smallest amount of testosterone.

[crony in reply to Tall_Allen]

Hey Tall Allen, I am wondering what the point of the test is if all it reveals is the mutation. How does this help the patient with changing the treatment, and what is to be changed?

[Tall_Allen in reply to crony]

That is not the only genomic mutation that it can potentially reveal. For example, if you had a genomic mutation in your BRCA gene, you might respond to a drug called olaparib. But, in most men with prostate cancer, genomic testing is not useful.

[StayingOptimistic in reply to Tall_Allen]

Wow, TA. “But, in most men with prostate cancer, genomic testing is not useful.”

I just learned a new concept in this disease. I really thought that genetic testing was very important.

[NanoMRI in reply to StayingOptimistic]

As I understand, genomic and genetic testing are different. I had the most helpful to me Genomic OncotypeDX of biopsy tissue prior to my first treatment decision. As I further understand, genomic testing is not applicable for me post treatments and when facing mets, whereas genetic testing is. But then, I am just a patient striving to stay ahead of this beast.

[StayingOptimistic in reply to NanoMRI]

Thanks for the clarification. I thought they are the same. It’s my fault

[Tall_Allen in reply to StayingOptimistic]

Maybe someday.

[NanoMRI]

Recently I posted about my Guardant360 result of 'Not Detected'. (Some say I had test too early and that it was of no value). One focus of mine with my medical team is to delay ADT for as long as possible, thereby hopefullly delaying CR. This is one of the papers they suggested I read (reading is easy; understanding, well that's challenging). ncbi.nlm.nih.gov/pmc/articl...

[Mgtd in reply to NanoMRI]

Loved your caveat! So very true of most of us on this train.

[j-o-h-n in reply to Mgtd]

I agree............. with your comment on Nano's caveat...... I would also apply that caveat to women...........

Good Luck, Good Health and Good Humor.

j-o-h-n