Liver Function Abnormalities Rare in Men With Metastatic Prostate Cancer Treated With Abiraterone Acetate

[snoraste]

From PracticeUpdate website:

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The authors report the management and outcomes of patients with elevated liver function test results secondary to abiraterone acetate therapy for metastatic prostate cancer. There were 46 liver disorder events seen in 25 men over 8 years at 3 French oncology centers. The median time from the start of treatment to the detection of liver toxicity was 7.1 weeks. In 52% of patients, liver function tests returned to baseline spontaneously while abiraterone was continued at full dose.

Liver events associated with abiraterone are rare and usually occur within the first 2 months of therapy. Most cases will resolve spontaneously."

practiceupdate.com/c/97495/...

[Jbooml]

What a gift this drug...and it’s ‘confreres’...

One feels...dare I aspire....confidence that, with it, and newer generational upstarts, life can amount to full span.

[Hirsch in reply to Jbooml]

We should be grateful to the physician who came up with it. What a godsend

[Hidden]

When I first started Abiraterone, I asked my doctor about this. He said he had not seen it yet with any patients. I asked him how many he currently has on Abiraterone and he said "About 2 dozen".

[GoBucks]

I had ALT & AST go close to 5 times normal in month 6. Stopped Zytiga for 7 weeks and gradually restarted, first 1/2 dose then 3/4 dose. No problems since 2 years.

[TommyTV]

Currently at 8+ years on Zytiga, Predisolone and Zoladex. No other treatments or dietary changes or supplements. PSA @ dx was 571, multiple major bone Mets, but Gleason 7 (4+3). Still quite well, but now developing osteoporosis due to ADT.

[snoraste in reply to TommyTV]

did you discuss Xgeva with your MO?

[TommyTV in reply to snoraste]

As I’m in the U.K., this is a new one to me, so I’ll bring it up with my Oncologist at our next meeting.

Thanks for bringing it up - I’d not heard of it before.

[snoraste in reply to TommyTV]

Great - there's been a study that shows lower probability of death by almost 20% for using Zometa plus Celebrex (An anti inflammatory) for the metastatic cohort. Zometa has some unpleasant side effects, which Xgeva does not. The combination of Xgeva and Celebrex may provide a similar benefit.

[Newyork6264]

For three months my ALT and AST trended normal. Then they shot way up. Doc took me off for a week and restarted me at 75% dose. First blood test after that showed high AST but normal Alt. Retested a few days later everything back to normal. So far so good after that.

[j-o-h-n in reply to Newyork6264]

Where are you located in NY? Where are you being treated? All info voluntary.... so no problem if you wish not to answer.

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 03/28/2020 3:52 PM DST

[Newyork6264 in reply to j-o-h-n]

Rochester NY. Treated at Pluta Cancer Center. Part of Strong Hospital.

[j-o-h-n in reply to Newyork6264]

As we here downstate (NYC) call you guys upstaters.... I go to Sloan Kettering... Good that you're being treated at a good center. Thanks for the info....

BTW Never tell a downstater that to get to the airport take CHILI avenue.....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 03/28/2020 4:03 PM DST

[Newyork6264]

Same to you. Got an opinion from Sloan since same as Pluta I decided to stay close. When I first moved here I asked a cop how to get to Chili and he corrected my pronunciation. Stay safe and stay healthy downstater. Lol.

[PeakClimber]

My ALT,AST immediately went a bit out of range and then continued to slowly climb. So stopped the abi, waited for normal LFT's then back on half dose but same issue. So switched to apalutamide. So far no problem. An ultrasound of the liver "looks excellent" per docs. Rare good health news much welcomed in my new reality...