Keytruda + LAVA-1207, new phase 1/2 trial

[Maxone73]

LAVA-1207 is a bispecific monoclonal antibody that acts by engaging prostate-specific membrane antigen (PSMA) to activate Vγ9Vδ2 (Vgamma9 Vdelta2) T cells that selectively target PSMA-positive tumour cells.

pharmaceutical-technology.c...

[KocoPr]

Very interesting!

pubmed.ncbi.nlm.nih.gov/363....

Development of γδ T cells in the thymus - A human perspective

Lena Boehme et al. Semin Immunol. 2022 Nov.

Abstract

γδ T cells are increasingly emerging as crucial immune regulators that can take on innate and adaptive roles in the defence against pathogens. Although they arise within the thymus from the same hematopoietic precursors as conventional αβ T cells, the development of γδ T cells is less well understood.

In this review, we focus on summarising the current state of knowledge about the cellular and molecular processes involved in the generation of γδ T cells in human.

I can’t wait to read up on this!

The thymus decreases it immunological activity around age 7 so this would be interesting if this monoclonal antibody reactivates a very important organ for child immunity.