Pluvicto supply increasing

[Tall_Allen]

Patients should be able to begin Pluvicto therapy within 2 weeks of qualifying for it.

novartis.com/news/media-rel...

[spencoid2]

i thought the shortage was over a while ago. i am getting it now. i was also told that it is still being made only in Italy or at least that is from where UCSF is getting it but it will be approved for making it in the US. absolutely absurd that we have had to get it overnighted from Italy all this time due to some fucking USDA regulations. How stupid can you get. Like we don't have accelerators or whatever is needed here. Fancy race cars that don't work maybe, but Pluvicto?

[MouseAddams in reply to spencoid2]

I think you’re getting the wrong information about the supply chain. When we were getting hubby treated his doses came from the facility in New Jersey. It’s been producing since last June according to his doctors.

[spencoid2 in reply to MouseAddams]

that makes me a little suspicious of information from UCSF.

[Brbnbrn]

Thank you TA! AND I should mention that my husband successfully completed his 6th Pluvicto treatment at University of Michigan yesterday!

Prior to the "last" treatment his PSA was 1.5! (Yay)

Doc's told us that they've had their 1st patient return for a 7th dose post 1st round when monitoring detected a small increase in his PSA.

It appears the supply if plentiful now! And used as a treatment option after that 6th dose. Only complication is kidney function with prolonged usage. Insurance IS paying for doses after the 6th also.

When he had his 1st dose last June, we had an overnight delay due to dosage shortages.

Like you said... plentiful now!

Barb 🌻

NOW to get him off.that AWFUL LUPRON!

[Brbnbrn]

Not Dr. Caram so far, but they are a well informed and coordinated team.

We love the staff at Rogel Cancer Center.

I pray for positive outcomes for you too!

[MJCA]

Hey Allen,

Hope you’re doing all right. It turns out 8 rounds of Docetaxel failed. My PSA keeps rising and a PSMA-PET showed more mets to my bones and now on the lymph nodes. I start Pluvicto next week. If that fails, what comes next? Sorry I haven’t attended any meetings; I’m just trying to deal with my own situation.

[Tall_Allen in reply to MJCA]

Cabazitaxel was designed for use when docetaxel fails. Have you had metastases biopsied?

[MJCA in reply to Tall_Allen]

No, I have not. Since the PET scan was a PSMA, doesn’t that indicate that it is cancer metastasized from the prostate? If so, how would a biopsy help?

Thank you.

[Tall_Allen in reply to MJCA]

Yes, it is prostate cancer - that is not questioned. But what kind of prostate cancer? And which therapy is it likely to respond to? I think you should ask for a biopsy and get a good pathology lab to do histology and IHC as well as genomics from Tempus or Claris. My wish list of IHC stains would include AR (androgen receptor), PSA, PSMA, MSH2, MSH6, STEAP1, PD-L1, PTEN, chromogranin A (CGA), neuron-specific enolase (NSE), synaptophysin (SYP),  DLL-3, CD56, Somatostatin (SST)

[MJCA]

All right. Thanks.