Got a copy of my Tempest test. My MO says "No actionable results" meaning plan of action doesn't change (Triplet Therapy). He also stated I had nothing to pass on to my son as far as hereditary gene problems. I have no clue what any of it means.
DNA mismatch expression (normal)
Homologous recombination (not detected) score of 4.
Pd-L1 Negative
Tumor proportion score TPS <1%
Combined Positive score <1%
PTEN copy number loss. Does this make me resistant to therapy?
(no potential germ line variants were found) ?
Tumor Mutational burden 0.5m/MB 2nd percentile
Microsatellite Instability (stable)
Blood tumor Mutational burden (3.8m/MB)
Microsatellite instability status MSI-High not detected.
I'd appreciate any education anyone could pass along to me about any of this . Thanks
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APK3
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I live here in middle America (Kansas). Dr. suggested right after biopsy. I'm 64 so no Medicare yet. Have decent insurance from my job that I retired from. The blood was sent to the wrong lab. Tempest wasn't the provered provider according to the insurance company. I ended up paying the non covered part. $700. Not a big it but could of been avoided.
1. The PTEN rearrangement is an intragenic deletion of exon 2. One of the breakpoints is within exon 2. 2. The TMPRSS2 - ERG fusion involves TMPRSS2 exon 1 and ERG exons 2 - 10.
MEAN OVERALL COVERAGE (SEQUENCING DEPTH) IN THIS SAMPLE: 356X
The following exons with OncoKB levels of actionability associations showed coverage of less than 100X. A false negative result cannot be excluded in these regions, especially in samples with low neoplastic cell content.
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