Genetic test

[APK3]

Got a copy of my Tempest test. My MO says "No actionable results" meaning plan of action doesn't change (Triplet Therapy). He also stated I had nothing to pass on to my son as far as hereditary gene problems. I have no clue what any of it means.

DNA mismatch expression (normal)

Homologous recombination (not detected) score of 4.

Pd-L1 Negative

Tumor proportion score TPS <1%

Combined Positive score <1%

PTEN copy number loss. Does this make me resistant to therapy?

(no potential germ line variants were found) ?

Tumor Mutational burden 0.5m/MB 2nd percentile

Microsatellite Instability (stable)

Blood tumor Mutational burden (3.8m/MB)

Microsatellite instability status MSI-High not detected.

I'd appreciate any education anyone could pass along to me about any of this . Thanks

[APK3]

Thank you MoonRocket..It is appreciated.

[Tall_Allen]

It means there is nothing currently available for your only genomic mutation (PTEN loss). Everything else is normal.

[APK3 in reply to Tall_Allen]

Thank you Tall_Allen.

[dhccpa]

Interesting that your doc even ran the test. Where are you receiving treatment? And was test covered by Medicare?

Thanks

[APK3 in reply to dhccpa]

I live here in middle America (Kansas). Dr. suggested right after biopsy. I'm 64 so no Medicare yet. Have decent insurance from my job that I retired from. The blood was sent to the wrong lab. Tempest wasn't the provered provider according to the insurance company. I ended up paying the non covered part. $700. Not a big it but could of been avoided.

[dhccpa in reply to APK3]

Thanks. Frustrating when insurance F/Us occur.

[j-o-h-n]

Good News..........roll up the rug and do a happy dance.........

BTW Get Your $700. back.... don't let them make you pay for their mistake.... That would be a mistake....

Happy New YearS to you and all.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/29/2023 5:44 PM EST

[StayingOptimistic]

Can you please help me understand this:

Summary: no mutations, no copy number alterations, 2 structural variants detected.

MSI Status: MICROSATELLITE STABLE (MSS). The MSIsensor score is 2.73.

TUMOR MUTATION BURDEN: Tumor mutation burden (TMB) for this sample is 0 mutations per Megabase.

POSITIVE FOR THE FOLLOWING SOMATIC ALTERATIONS:

1. PTEN (NM_000314) rearrangement: c.80-782_c.85del (Note: 1)

2. TMPRSS2 (NM_001135099) - ERG (NM_182918) fusion: c.55+2848:TMPRSS2_c.18+4607:ERGdel (Note: 2)

Notes:

1. The PTEN rearrangement is an intragenic deletion of exon 2. One of the breakpoints is within exon 2. 2. The TMPRSS2 - ERG fusion involves TMPRSS2 exon 1 and ERG exons 2 - 10.

MEAN OVERALL COVERAGE (SEQUENCING DEPTH) IN THIS SAMPLE: 356X

The following exons with OncoKB levels of actionability associations showed coverage of less than 100X. A false negative result cannot be excluded in these regions, especially in samples with low neoplastic cell content.

CHEK2 (NM_007194) exon14 (488-514), exon13 (459-487), exon12 (420-459) PIK3CA (NM_006218) exon12 (583-637), exon14 (672-729)

[StayingOptimistic]

Thank you for replying. It was a blood test in MSK. it’s called the IMPACT, I think. My MO said the same thing”no actionable treatments “

[StayingOptimistic in reply to StayingOptimistic]

Sorry, I think they run the test on 11/2020 on my prostate that they removed on 12/2012.

[StayingOptimistic]

Do you know if these mutations speed up the time to castrate resistant? Thanks