177Lu-PNT2002 Significantly Improves rPFS Vs ARPI in Metastatic Castration-Resistant Prostate Cancer

[Maxone73]

onclive.com/view/177lu-pnt2...

Lutetium seems to be a radiological miracle! Or maybe is the pr2002

[Tall_Allen]

You buried the lede. Far from a "miracle," it did not improve survival. I doubt the FDA will approve it.

[Maxone73 in reply to Tall_Allen]

You buried my joy! 😃😃 we will see about FDA, personally I have never found pluvicto so exciting looking at its results, but maybe because it’s been use at very late stage

[Tall_Allen in reply to Maxone73]

I agree. I think Pluvicto and Xofigo will really prove useful when they are used earlier, while men are still hormone sensitive.

[jersy]

a miracle?? Seems more like false hope.

[Maxone73 in reply to jersy]

Well rPFS is longer, data still immature for OS but in general Lutetium does not seem to perform that better than other systems even if for some individuale it does and improves QoL (the doesn't mean much to me as even with Provenge when it works it works well). But as I said, I think Lutetium (and even more actinium) should be tested in some early stage situation to understand their full potential.

[Miccoman]

Pluvicto is working very well for me. I am lucky to be among the 30% who fall in that category. I fully agree that this, and the related actinium and copper therapies (now in trials) as soon as they are approved, should be offered before chemo.

For me chemo was horrible and only lead to a huge decrease in QOL, from which I am not fully recovered -- hard to tell due to another treatment that went sideways at the beginning of this year.

I just cannot fathom why doctors would want to subject their patients to such a destructive and life changing therapy (chemo) when there is another path that is easier and has less side effects. I guess taxanes are still under patent in the US...

[Maxone73 in reply to Miccoman]

well I am under triplet therapy: adt + nubeqa + chemo...but I am lucky, almost no side effects and complete blood recovery between infusions (still one to go) plus zometa (I think it's a quadruple therapy at this point). I realize that I am lucky, in shape and lucky (for now) as QoL was not touched by taxanes, but having bone metastasis I would like that Actinium thing that seems to be ideal to kill micro metastasis as well!

[Miccoman in reply to Maxone73]

I thought it was interesting that the study noted that all the subjects were on opioids for pain -- I got steroids to go with Pluvicto and that has prevented that. It's another way I am lucky as I do not respond to opioids like others in that they do not work until I am unconscious. But a couple of Tylenol and pain goes away. Go figure!

[Maxone73 in reply to Miccoman]

We are all very unique!

[Benkaymel in reply to Maxone73]

You are lucky. Docetaxel has kicked my butt - total exhaustion wipe out has shot my QoL to bits.

[Maxone73 in reply to Benkaymel]

Yes I know! I got some side effect, but till today I got the most stupid ones, like nails discoloration, lost my beard (but not my hair for some reason), altered sense of taste for few days, some fatigue on the 3rd day after chemo (always the 3rd), but apart from that I still workout 5 times per week and do everything as usual.

But are you still under chemo or recovering?

[Benkaymel in reply to Maxone73]

Still doing chemo - done 3 out of 10 cycles so far 😕

[Maxone73 in reply to Benkaymel]

Damn, good luck brother. Mine is only 6 cycles. You use supplements, I suggest milk thistle between sessions for your liver values, it works for me, I was skeptical but I saw that my bloodwork after the third infusion was better than the one after the first.

[Benkaymel in reply to Maxone73]

Thanks. Yes, I take several supplements including Milk Thistle each day.

[Benkaymel in reply to Miccoman]

Yes, it's all about the cost.