Enzalutamide approved for patients with high risk of metastasis

[Maxone73]

onclive.com/view/fda-approv...

[PCaWarrior]

Clinical trial: Phase III trial of an adaptive therapy with excellent results. AUA 2023: EMBARK: A Phase 3 Randomized Study of Enzalutamide or Placebo Plus Leuprolide Acetate and Enzalutamide Monotherapy in High-Risk Biochemically Recurrent Prostate Cancer

urotoday.com/conference-hig...

[KocoPr]

Excellent bit I would like to see how darolutamide/Orgovyx with same criteria

[Hidden]

I discussed this with my MO just days ago.

The trial was meant for initial use of Xtandi for nonmetastatic castration-sensitive prostate cancer.

If you're metastatic, you start with Zytiga, then got to Xtandi when becoming castration-resistant.

[RJAMSG in reply to Hidden]

How long were you “<“ after the RP?

[Hidden in reply to RJAMSG]

First PSA test at 90 days.

[RJAMSG in reply to Hidden]

So after the 90 days the psa remained at very low levels “.0 something” but never had the < again

[Hidden in reply to RJAMSG]

Undetectable, was <0.1 for 4 years. Starting with the first PSA test at 90 days post op. Then every 3 months for a year, then yearly. 0.2 appeared at 51 months post op.

PSA tests were not ultra sensitive, as any salvage treatment would not be considered until 0.2 or greater. Treatment was started when reached 0.4

[Hidden]

Your bio shows you as 3TbN1MO. N1 is metastatic, albeit near, but still metastatic.

I am N1 now too, hence my MO saying I was metastatic, even N1 is considered metastatic, and do not fit in that trial.

[Hidden]

Please calm down. Its not a pissing contest, but a friendly debate.

As far as my MO and RO one lymph node is metastatic, N meaning NEAR metastatic (oligometastatic ). For the purpose of the Xtandi FDA approval mentioned above, N1 is metastatic in their eyes. It'smeant for confined to the prostate.

So let me ask you , why Xtandi, and not returning to Zytiga?

[Hidden]

I stated with RP in 2018!! Ive been at this longer!!😜

[Hidden]

Im BCR too. Went over 4 years after RP, with PSA undetectable.

At .4 my team (I dont drop names) decided to start with Zytiga, and WPRT with extended field lymph nodes. Saving the Xtandi in case I become resistant.

Im PSMA clear in one year, and <0.02 PSA but I'll have Xtandi, in case of another BCR due to resistance. Or maybe Its cured. Going to stay on Zytiga one more year.

[Hidden]

Typo 0.4

I didn't restart. No ADT after RP, I was N0M0 at the time

My bio has the right numbers

[Plaxsis]

Ok, end of round 5. Go to your corners.

[Maxone73 in reply to Plaxsis]

😂😂

[MateoBeach]

Good plan, MoonRocket

[London441]

Indeed. What seemed like the back and forth of an argument between 2 guys with the same pathology was an illusion! They can kiss and make up now.

[London441]

I've been called worse😀

[j-o-h-n]

I call my sugar Xtandi....................... (enzalutamide)...

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 11/20/2023 6:12 PM EST