Advanced PCa & the Mediterranean diet in the Netherlands.

[pjoshea13]

New study below [1].

There were "3868 prostate cancer cases (advanced: 1256)".

With a third of the cases being advanced, it looks like a considerable number of men in the Netherlands don't screen for PCa.

"Higher levels of care-seeking behavior, screening attendance and prostate cancer awareness in higher educated men with healthier lifestyles could potentially explain the positive associations that we observed for nonadvanced prostate cancer risk."

"aMEDr {alternate Mediterranean diet score without alcohol} was not associated with advanced prostate cancer risk [HRper two-point increment (95% CI)=1.06 ...]. In contrast, higher aMEDr values were associated with a significantly increased risk of nonadvanced prostate cancer ..."

"MD {Mediterranean diet} adherence does not seem to reduce the risk of (advanced) prostate cancer".

What is a Mediterranean diet without alcohol?

What do they drink instead?

Milk! LOL

The Netherlands is 3rd in milk consumption. The U.S. is 16th. [2]

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/312...

Cancer Epidemiol Biomarkers Prev. 2019 Jun 24. pii: cebp.0224.2019. doi: 10.1158/1055-9965.EPI-19-0224. [Epub ahead of print]

Adherence to the Mediterranean diet and risks of prostate and bladder cancer in the Netherlands Cohort Study.

Schulpen M1, van den Brandt PA2.

Author information

Abstract

BACKGROUND:

Prostate and urinary bladder cancer are frequently occurring cancers with few risk factors identified. We examined the relation of Mediterranean diet (MD) adherence with risks of prostate and bladder cancer in the Netherlands Cohort Study (NLCS).

METHODS:

Data were available for 58279 men and 62573 women, who completed a baseline questionnaire on diet and other cancer risk factors. Multiple MD scores, including the alternate Mediterranean diet score without alcohol (aMEDr), were calculated to assess MD adherence. After 20.3 years of follow-up, 3868 prostate cancer cases (advanced: 1256) and 1884 bladder cancer cases could be included in multivariable Cox proportional hazards analyses.

RESULTS:

aMEDr was not associated with advanced prostate cancer risk [HRper two-point increment (95% CI)=1.06 (0.96 - 1.17)]. In contrast, higher aMEDr values were associated with a significantly increased risk of nonadvanced prostate cancer (ptrend=0.04). For bladder cancer risk, no association was observed with aMEDr [HRper two-point increment (95% CI)=1.00 (0.92 - 1.09)]. Absolute scores based on the WCRF/AICR dietary recommendations were not associated with prostate or bladder cancer risk.

CONCLUSIONS:

MD adherence, measured by aMEDr or other MD scores, was not associated with decreased risks of advanced prostate cancer and bladder cancer in the NLCS. Higher levels of care-seeking behavior, screening attendance and prostate cancer awareness in higher educated men with healthier lifestyles could potentially explain the positive associations that we observed for nonadvanced prostate cancer risk.

IMPACT:

MD adherence does not seem to reduce the risk of (advanced) prostate cancer or bladder cancer.

Copyright ©2019, American Association for Cancer Research.

PMID: 31235470 DOI: 10.1158/1055-9965.EPI-19-0224

[2] en.wikipedia.org/wiki/List_...

[NPfisherman]

Thanks for posting...

Fish

[whatsinaname]

Thanks for the study.

[Hidden]

well, with the milk involved it's is difficult to tell if the mediterranean diet helps... I mean, in the Netherlands they drink lots of milk (one of the reasons they are so tall)!

[pjoshea13 in reply to Hidden]

The tallest people in the world.

Dutch men are, on average, 1.838m (6' 3.6") and the women are 1.71m (5' 7.3")

Shows the power of IGF-I to me. But that's just an observation - doesn't prove causality. LOL

-Patrick

[Hidden in reply to pjoshea13]

well, they weren't tall before:

In the mid-1800s, the average Dutchman was about 5ft 4in tall (1m 63cm) - 3in (7.5cm) shorter than the average American. In 150-odd years of scoffing milk and cheese, however, the Dutch soared past the Americans and everyone else. These days, the average Dutchman is more than 6ft tall (1m 83cm), and the average Dutch woman about 5ft 7in (1m 70cm). The Dutch have gone from being among the shortest people in Europe to being the tallest in the world.

Not sure if diary is the only cause, but sure an important one.

Would be curious about prostate cancer stats in the Netherlands....

[pjoshea13 in reply to Hidden]

The problem with Dutch stats is that for those who lived through the German occupation (1940-5), including the 'hunger winter', their bodies would have produced minimal amounts of IGF-I during that period. Then there was post-war austerity. Today we have the affluence that has created giants.

So I would expect stats to differ dramatically by generation. It could be some time before we see how the tall ones fare. We know that height is a PCa risk factor.

-Patrick

[j-o-h-n]

You'd measure taller also if you were wearing those wooden shoes.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/28/2019 2:21 PM DST