Some positive news from Lancashire, innit?

[Maxone73]

christie.nhs.uk/about-us/ne...

[Hidden]

He had an “ATM” mutation

[Maxone73 in reply to Hidden]

Like me…and some others

[MoonRocket]

I think I read about this fella before...good to know a ATM mutation was successful treated. Hoping to staying AR treatable for some years so these inhibitors are fully vetted. I wonder what other mutations were detected in addition to ATM?

[KocoPr]

It’s great that it only targets cancer cells. The drigs and treatments are getting better very quickly.

[PCaWarrior]

ATM: facingourrisk.org/info/here...

I don't have any mutations but have used olaparib with SBRT and during the initial injection of BAT. Sartor, my MO, and the head of ASTRO and a BAT/olaparib clinical trial all agreed that it would help.

Your case is even clearer. Talk to your MO.

[Maxone73 in reply to PCaWarrior]

My MO already talked about olaparib for the future in case I needed it. But there seem to be better options now as olaparib seems to work not so greatly on ATM mutations (but still better than on non mutated people). I wanted to introduce the subject of BAT giving him some references because when I hinted it he said it’s still not a well tested approach. But I would still like to talk to him about it once I am done with chemo.

[PCaWarrior in reply to Maxone73]

It doesn't look great as monotherapy or combined with ADT.

I think the real value is with BAT and RT and some types of chemo. Even so, it is only an addition that helps the core therapies.

There are a dozen completed BAT clinical trials and another eight in progress. Given the constraints Denmeade has to work with, the trial implementations aren't optimum.

[PCaWarrior in reply to Maxone73]

STEP-UP trial might bring BAT into more prominence. There are 20 completed or in-progress clinical trials plus many informal studies including my own study of 14 men. Even without any optimization of times, testosterone formulas, or serum T levels, the evidence speaks clearly.

classic.clinicaltrials.gov/...

[pd63]

I'm from Lancashire, innit isn't exclusive to the region LOL

[Maxone73]

I know but it’s UK at least! Appreciate the effort 😜😜

[TJGuy]

cancernetwork.com/view/onct....

[Maxone73 in reply to TJGuy]

yep! Posted already but under a different thread. I have a feeling of big news in crispr cas9 applications within 6 months

[KocoPr in reply to Maxone73]

I think the CRISPR cas9 will be our salvation!

[Maxone73 in reply to KocoPr]

A friend of mine is betting on that…

[Maxone73 in reply to KocoPr]

Lately I am not sleeping well because I am afraid the problem won’t be a cure itself but the length of a testing process and pipeline that was created decades ago. Knowledge is increasing so quickly nowadays and we are not keeping up on the practical development side.

biospace.com/article/study-...

[KocoPr in reply to Maxone73]

Plus at 1 to 2 mil per treatment is a little much

[Maxone73 in reply to KocoPr]

science.org/doi/10.1126/sci...

[TJGuy]

cancernetwork.com/view/pemb...

[TJGuy]

medicalnewstoday.com/articl...

[TJGuy]

cancernetwork.com/view/nove...

[TJGuy]

cancerprogressreport.aacr.o...

[TJGuy]

freethink.com/health/crispr...

[TJGuy]

cityofhope.org/city-hope-sc...

[Maxone73 in reply to TJGuy]

Largely oversold…. Read their trial first 😀

[TJGuy]

healthunlocked.com/advanced...