So I thought that I would raise my my hand and say “I’m on the trial!” It’s NCT02266745, and here’s the URL that Maxone73 posted: prnewswire.com/news-release....
Back in August, my MO waved his hand and said that, with all of my mutations, what do you even call this cancer anymore? He says I need something that will affect a broad range of cancers (mine is mCRPC with neuroendocrine differentiation). So his recommendation is this drug that is a platinum pyrophosphate and looks like a chemotherapy agent, but it doesn’t interfere with DNA. I feel like I barely understand it, but what I've learned is that it finds damaged cells and causes signals to be released that trigger your immune system. It takes time for your immune system to get trained, so I’m told that it can take some perseverance. You can get “phantom” progression where the immune cells pile into a cancer spot, making them bigger, when in fact it’s just a sign of the battle going on.
I’m on Arm 3, which starts with two big doses two weeks apart, and then goes to a lower dose once a month. From the side effects, it feels like about 10 percent of what chemotherapy felt like to me (docetaxel+carboplatin). After a few days of mild nausea after each treatment I mostly feel fatigued and foggy, but I'm still continuing to work.
I’ve had three treatments so far, and am just getting my first set of scans back. I interpret them as mixed, some LN got bigger, some smaller, and some stayed the same. I think that, given the slower nature of this process, my MO will suggest staying the course, we shall see when I talk to him in a couple of weeks. Tall_Allen is correct in that you get a lot of attention in a clinical trial, and you no longer have to deal with making appointments, they make them and tell you where you need to be and when!
I'm so far optimistic and going with the flow, we'll see where this takes me.
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Thanks for everyone's support! I got a bit of a chill, once I posted this message it also highlighted the fact that our dearly departed Cleodman had tried this a few years ago and it didn't work for him. I think they've been working on how to dose it and what to look for. Fingers crossed.
As I've said many times here on HU, The Immunotherapy drug Keytruda was used to treat my melanoma lung metastasis, and so far it worked..... (Not for Pca use however). I never use the word "cure" when it comes to ca..............(So fuck you ca.... wherever you're hiding you little turds, probably with my ex-wife).....
That sounds like a PARP inhibitor, available to BRCA (breast cancer - causes prostate cancer in men) 2 gene failure type people in Australia for free(ish), like me, as I currently understand it, once I go castrate resistant. Not yet there, heading for 12 years into this last ride now.
so who exactly is likely to benefit from this? i just got the results of ct and bone scans and it looks like the 10 rounds of doxytaxel did essentially nothing. PSA doubling is .9 months and i have new bone mets and cancerous (were biopsied) lymph nodes that have quadrupled in volume since last scan just a couple of months ago. I have the cdk12 mutation which limits what might be effective and am trying to get all the information i can get for my next MO visit.
is this trial ongoing? can not find it on clinicaltrials.gov so can not assess how useful it might be fore me.
The theory is that it should help with all solid tumors and they have finished trying it with thymoma and the CRPC portion is still open. From the pieces I've read here and there it sounds like it's not something that helps everyone and I think that part of it being a Phase 2 trial is seeing who it does help. I have no problem finding it, go to clinicaltrials.gov and put in the NCT number from my original post into the "other information" search field.
thanks i missed that one. the only nearby one i found was not for people who had had chemo . i have an appointment in a month but hopefully sooner with Dr. Aggarwal at UCSF and he should know about this one
Hi, here's an update on my experience with the PT-112 trial. My doc wanted to give this drug a good chance as apparently some people give up too quickly while some immunotherapy drugs take a while to kick in. I did five infusions from August to November 2023. I'm off the trial now, and I can say that I think it helped some, but not in the ways we needed.
If the measure of success were carcinoembryonic antigen (CEA), that marker went down following each of my five infusions. If it were chromogranin-A (CGA), it was relatively stable, bouncing around with a maximum of about 175. But my PSA went up linearly between every infusion, and when it started going up exponentially after infusion #5, we decided to stop. Midway through the trial my scans were interpreted as "stable disease," but then when we scanned in December we saw progression.
I have mixed PCa and treatment-emergent NEPC, and to me the markers show that the PCa is what's out of control since the CGA hasn't been going up as fast as PSA. I'm nine years into this adventure, and haven't yet had enzalutamide, and that, plus either a PARP inhibitor, or a rechallenge of Lu177-PSMA are next. Meeting with my doc this afternoon to get the gears turning.
Note that our former esteemed member Cleodman also did this trial and you can see his comments if you are into researching it.
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