Melatonin

[Teufelshunde]

I just watched this and it was fascinating. I know this is not double blind study quality, but I like his style and philosophy. Melatonin does not have a LD50. None. zero. It is near the end but worth the wait. IMO.

chrisbeatcancer.com/dr-russ...

[Nusch]

I take between 10 - 20 mg Melatonin before bedtime.

[kaptank]

Thanks. Very interesting. I take 20mg before bed but every few months I up the dose to 60 for a month.

[RonnyBaby]

I take 40 mg 1 hr before bedtime. 20 mg is Timed Release - the other 20 is quick dissolve. I recommend it for PCa patients .... been doing it for years.

[Nusch in reply to RonnyBaby]

Which pills are time-released?

[RonnyBaby in reply to Nusch]

I live in Canada, so the Brands might be different - however, you should be able to find something from Amazon - note you want 10 mg size.

I can tell you 'Jamieson' is one for sure and I believe Weber Naturals also supply them.

[Nusch in reply to RonnyBaby]

Many thx!

[Teufelshunde in reply to RonnyBaby]

I am thinking of adding a time release. What brand do you use?

[RonnyBaby in reply to Teufelshunde]

I live in Canada, so the Brands might be different - however, you should be able to find something from Amazon - note you want 10 mg size.

I can tell you 'Jamieson' is one for sure and I believe Weber Naturals also supply them.

[Purple-Bike in reply to RonnyBaby]

Is there good evidence some Timed Release is better?

[RonnyBaby in reply to Purple-Bike]

I chose the time released version as a sleeping aid.

I'm a severe insomniac and use several 'formulations' to sleep.

My total nightly dose of melatonin is 25 mg - 15 mg of time released and 10 mg of the fast dissolving.

I do recall reading about a minimum target of 20 mg 'daily' to TRY to achieve some positive results.

SOME people could have nightmares / vivid dreams at high(er) doses - I certainly do - but I'm used to it and my dreams aren't nightmarish - more like adventures and going back to my youth is much more typical. I don't recall waking from a 'bad' experience.

[katartizo61]

I favor a liquid product from Optimal Health. I take a dropper 2 to 3 x a day. Clean and feel good

[Sandy752]

Maybe just me but both times I took 10 mg before bed I had such awful nightmares that my screaming in my sleep woke my wife.

[Teufelshunde in reply to Sandy752]

I do have more vivid dreams and actually remember them mostly. Wife has some scary ones, mine tend to be more solving things, some danger, more of an action movie. For us, it seems to more accentuate what dreams we had before.

[Hidden]

Thank you for posting, my husband takes 60mg every night. I also read the list of supplements that chris recommended and looks like we have those covered as well. I say give this all you have, why not throw everything at it.

[j-o-h-n]

Melatonin is a very popular med on our forum...... (do searches if need be)

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 05/04/2022 10:56 PM DST

[jazj]

It's crazy, just when I thought I looked under every rock I run across something new I hadn't uncovered. (I realize I'm playing catchup to a lot of people on this forum.) I was reading an interesting article on Breast Cancer and noticed it came from a site called Cureus, I never heard of. So I went there and popped in the search for: prostate cancer of course and I'm now scanning through the articles and stumble on this... (20 year study!)

My question is... what's the downside to taking such high amount of melatonin?

EDIT: Found reference to this study in an older thread of course but will leave it in. It's no silver bullet, like all the other supplements. But interesting. I always though taken too much melatonin could then make your body think it didn't need to produce as much on its own so if you go off it, hello insomnia. But that's just theoretical.

cureus.com/articles/64895-m...

The use of melatonin with conventional PC therapy has shown therapeutic benefits. A recent retrospective study in Russia that spanned 20 years assessed the effect of melatonin on the survival rate of prostate cancer patients with varied prognoses. Out of 955 participants, 113 had a favorable prognosis, 187 had an intermediate, and 655 had a poor prognosis. All participants received combined hormonal and radiation therapy with or without 3 mg of melatonin daily. The study revealed a statistically significant improvement in the five-year survival rate (153.5 months vs. 64 months; P < 0.0001) of those with poor prognosis treated with melatonin compared to those not treated with melatonin. However, there was no statistically significant improvement among the patients with favorable and intermediate prognoses [28]. This reflects the beneficial effects of melatonin in advanced prostate cancer patients with poor prognosis, and more research is encouraged to investigate when it is feasible to start melatonin treatment in those with intermediate prognosis who might progress to poor prognosis.

[Teufelshunde in reply to jazj]

Interesting. However, I see no logical reason why one would wait until poor prognosis to start this. There is literally no downside (other than personal intolerance) and on animals has no dosage that causes death, no matter how high they went.

[KocoPr]

I don’t believe anything Mercola has to say.

The Most Influential Spreader of Coronavirus Misinformation Online

[CAMPSOUPS in reply to KocoPr]

Agreed. Another "Internet Businessman" pretending to spread the information of a Dr.

[Purple-Bike]

I take 20 mg before bedtime. When I ran out of it, I was afraid insomnia would erupt but it didn't. Reinforces that supplementation does not affect endogenous melatonin production.

[KocoPr]

Londinium, your bio says “nothing to see here”. Can you update it