If 3 men in the same family, father and two sons all dx with Pca at exactly the same age (66) two were metastasized, one had timely RP. How is this not genetic,? Coincidental? Bad luck? And what,'s in store for their sons,? We don't get that it's not, apparently.
I'm thinking these men in their late 40s better get tested for the genes. Correct?
As the saying goes 'genetics loads the gun, but the environment pulls the trigger.'
Basically, even though your genetics sets up the situation to be more supceptible for PCa, the environment must also right.
IMO, and I'm sure tha lots will disagree, pulling out a gene sequence from a ridiculously complicated biochemical system with all kinds of feedback loops and living parts interacting and finding a 'cause' is extremely optomistic. People can't even agree on how the body works so I'm not sure how they can find it's design flaws. Afterall, if they could, the human genome project would have fixed all our flawed gene designs.
It's like pulling out a transistor from a spaceship and thinking you've found the reason the self distruct was on countdown.
Edit: oh and by the way, you've got epigentics which is a layer ontop of your genes. Good luck with all that.
Researchers estimate that the genetic factor is about 20%. You can get a free germline test here:
Unfortunately, US residents only.We live in Canada and will have to access genetic tests thru our doctor.
Thanks anyway.
my dad had I think intermediate prostate cancer he never told me the grade he died of old age at 99 in 2021. He was diagnosed in his early 70s. I was diagnosed last year at 66 with Gleason nine, and my younger brother based on my diagnosis got checked, and he had a Gleason 8. So somethings in the water.
My dad had curable pca died with it not of it age 89. He or our shared gp never told me that there was the 20% factor that TA mentioned . I got tests on 1st symptoms age 49 already G9 PSA 342 and spread . I have now met men who have got it and even died of it in their 40s as such I have told my two sons to get tested from 40 onwards .
Because my husband (Gleason 10 aged 63) had a brother and niece with pancreatic cancer, and mother with breast cancer, we have been told by the NHS genetic counsellor to instruct our son to start PSA screening at age 40 and our daughter to start breast screening at age 35.
He has been to the Royal Marsden for genetic testing and the results are due this month. He is dreading finding out he may have caused a predisposition for them, but forearmed is forewarned, so at least they have the chance of getting diagnosed early.
My husband as well diagnosed at 65, stage 4 with a couple of bone mets, PSA 8 and Gleason 7+3. His father died at 60 from PCa. Genetic testing showed BRCA2. My daughter tested and was negative for BRCA. Son doesn't want to get tested yet.
The stats show that approx 1 in 8 men in the UK get PCa. That rises to 1 in 3 if you have a close family member who has/had the disease.
Hi. I have genetic testing done because I'm a 3rd generation with PCa. There are specific mutations that point to PCa. I highly recommend it, although with your hereditary PCa, all males in your family have a much higher risk anyway. My geneticist said this means PSA testing etc. should start much earlier than those without that disposition. It's not preventable, but very early detection, as we all know, can be soooo important.
My MO told me cancer is caused by: bad luck, bad lifestyle, bad genes. On that last front, 11 more have been discovered. See icr.ac.uk/news-archive/scie...
Just a data point: my 4-year younger brother and I had back-to-back RPs the same day at the same hospital. A few months later our cousin, the only other male in our generation on my father's side, was diagnosed. My uro moved to the Univ. of Pittsburg and all 3 of us donated blood for a genetics study they were doing there.
Environmental exposure to carcinogens is the hidden killer. Most people don't know what is in their water, under their house - seeping thru the foundation walls, or in their food. A family unit gets one set of carcinogen exposures. A work environment is another set of carcinogen exposures. If the men in a family work in the same field, the effects are additive, they all have the same exposure. There are federal limits for each known carcinogen which may or may not be observed. If everything is just barely meeting the specification and the work environment is full of different carcinogens, the total exposure can cause trouble, especially if someone is a smoker.
Genetic influence is different for father than for the sons who have only half his genes. They have half their maternal genes. This can be good or bad. Life is a gamble, have safe fun.
I will not bore you people with my theory about CANCER. All I can say is that we all are born with those tiny little fuckers eating us alive.....
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 10/05/20233 3:13 PM DST
Boring! (In a good way.) 
My husband has passed.
Who is bothered most by ADT side effects and why?
Great Words by Dylan Thomas - praying we all don’t go down easily in this struggle. 
