liver nodules

[Chris52981]

Has anyone had very small .6 cm hypodense liver nodules (with heptix steatosis) seen on ct scan that were not metastatic prostate cancer- ?

[timotur]

Yes, after ADT, I developed the same hypodense liver nodules that were caught on a Calcium Score test. Physically, I noticed it when doing floor exercises on my stomach— felt like a sore rib on the upper right side of the rib cage. Went to a heptologist, had an MRI, and was graded out just below the threshold for NAFLD. She she said not to worry, was significantly less than level to treat. Read some studies that show association of ADT with hyper insulin-sensitivity, and attributed it to that. It’s pretty much dissipated now three years after ADT. I did cut back on carbs, which may have helped.

[Chris52981 in reply to timotur]

Ok thank you- my dad gets them checked again to make sure they are stable they don't think it's prostate but they want to be sure I'm a nervous wreck

[Chris52981 in reply to timotur]

How did they know it wasn't prostate that metastasized

[timotur in reply to Chris52981]

PSA was <0.02 and no evidence of NEPC. Probably MRI signature was specific for hypodense fatty nodules, which were white, as opposed to PCa mets, which would be dark.

[Chris52981 in reply to timotur]

my dads were hypodense on ct scan which I guess is dark is that what ur were on ct scan- but mri different color

[Magnus1964]

I have had a cyst on my liver for decades. No problems with it

[Chris52981 in reply to Magnus1964]

Ok thank you- my dad gets them checked again to make sure they are stable they don't think it's prostate but they want to be sure I'm a nervous wreck

[Magnus1964 in reply to Chris52981]

It is discernable by CT scan whether it's a cyst or tumor.

[Chris52981 in reply to Magnus1964]

ThesI were too

Small to determine

[Benkaymel]

This is very timely for me. At. Friday's MO meeting he told me some small "lesions" have appeared in my liver so we need to move to chemo. I'm not convinced they are PCa mets as a scan last year showed a few loci in the liver. If ADT can cause nodules, I will challenge him about this at my next meeting.

[Chris52981 in reply to Benkaymel]

Did they find this on Ct scan and how big were they

[Benkaymel in reply to Chris52981]

Yes, CT scan and they're very small spots.

[Chris52981 in reply to Benkaymel]

How do they know they were cancer - my dads were indeterminate so they r rechecking to see if they grew

[Chris52981 in reply to Benkaymel]

Did they say they are cancer

[Benkaymel in reply to Chris52981]

He thought it was cancer but did say he would check if they were big enough to be biopsied.

[timotur in reply to Benkaymel]

Your Uro needs to read these studies!

In an editorial accompanying the study by Dr Trinh and his team, Jehonathan H. Pinthus, MD, of McMaster University in Toronto, commented that the finding that ADT is associated with a greater risk of liver disease, particularly non-alcoholic fatty liver disease, “is an important observation because it highlights a clinically important metabolic perturbation of ADT which is probably unfamiliar to most urologists.”

renalandurologynews.com/hom...

pubmed.ncbi.nlm.nih.gov/323...

[Chris52981 in reply to timotur]

Yes my dad has that so that's what they think the nodules are drom

[Benkaymel in reply to timotur]

Thanks I'll point these out to my MO.

[j-o-h-n]

I know that having Pca drives us slightly insane..... but please don't be a nervous wreck.... Regarding your Dad's liver nodules....... they're probably a nuttin bagel........ BTW how old is your Dear Dad?.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 09/25/2023 10:26 PM DST

[Chris52981 in reply to j-o-h-n]

He is 80 thank you- they think it's just from fatty liver and fibrosis nodules but I'm still so worried

[j-o-h-n]

Worry Warts,,,,,,Probably spread by you🤢............. God Bless your 80 year old - war baby DAD, give him my regards....as for you, have a sarsaparilla on me (not literally, please)....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 09/26/2023 7:04 PM DST

[Chris52981 in reply to j-o-h-n]

Ct scan was good God bless - it looks like fibrosis thank God

[j-o-h-n in reply to Chris52981]

Way to go Dad-dy-o............ (okay software programmer guy, put three smiley faces here XXX). Nothing like a DAD - mine left us in 1955......

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 09/26/2023 8:00 PM DST