Study shows curcumin and quercetin combination inhibited proliferation and arrested the cell cycle, inducing apoptosis

[Graham49]

Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate CancerMichele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci

Biomedicines 11 (7), 2023, 2023

Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms underlying the effects of CUR and QRT have not been fully understood yet, and most investigations were conducted with individual compounds. Here, we investigated the anticancer and anti-inflammatory effects of CUR in combination with QRT, respectively, in a human prostate cancer cell line, PC-3, and in LPS-stimulated RAW 264.7 cells, and found that their combination significantly inhibited proliferation and arrested the cell cycle, inducing apoptosis, so exhibiting synergic activities stronger than single drug use. Moreover, via their antioxidant effects, the combination of CUR and QRT modulated several inflammation-mediated signaling pathways (ROS, nitric oxide, and pro-inflammatory cytokines) thus helping protect cells from undergoing molecular changes that trigger carcinogenesis. Although additional studies, including in vivo experiments and translational studies, are required, this study raises the possibility of their use as a safe, effective, and affordable therapeutic approach to prostate cancer.

[85745]

Interesting, , ck out Ursolic acid in combo with Curcumin

[Stoneartist in reply to 85745]

I like the approach which observes the enormous difference between PCa in the west and east. Its also good to see studies of chemicals in combination, and that benefits come with low doses without being significantly better at high doses. Since these chemicals are readily available in foods it suggests once again that we can influence PCa by what we eat.

[RJAMSG]

Many drugs come from plants so it’s interesting to hear of different combinations that naturally help fight against disease and there is likely no money involved for big Pharmaceutical companies so you are left to do your own research/results. Thanks for the information 😊

[Captain_Dave]

Long ago, I read that quercetin and green tea was a good combo. I take quercetin with my cup of matcha tea everyday.

[j-o-h-n]

Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci. Any of these researchers mention pasta?

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 07/30/2023 2:00 PM DST