In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs.
This type of metabolic Achilles’ heel will allow us and others to more effectively “starve” the CSC population.
Fantastic facts and theories in this paper. I particularly appreciated learning that The ‘Mito-high’ cell sub-population also had the highest tumor-initiating lymphocytes (TILs) as I have been looking at TILs for 40 years.
However, one should emphasize it is a cell line (pre-clinical study) and therefore, hypothesis-generating only, as far as clinical therapeutic effectiveness. Nonetheless, I really appreciate you bringing this thought-provoking article to my attention. And I hope others find it useful in their prostate cancer journey.
At the moment I am still doing fine on standard of care but as we all know the cancer stem cells are there to get us.
Therefore it is only an add on and only to kill CSCs.
I really would like to get provenge but it is only available in USA. In other countries provenge is not even approved. It is a big concern for me as I believe provenge is killing the CSCs otherwise it would not be effective. It is only my opinion.
One must be careful that interferring with one process to hinder cell dev may restrict other processes that are slowing things down anyway. I dont have the source handy but recall numerous references as to why Vit C megavitamins are detrimental.
Yes, they are side effects. You can search the internet. When I was young I was taking at least 5g vitamin C per day without having problems. And I was not the only one. I belive last time long time ago they advised me that 2g per day is a maximum what a pharmacist would recommend. I never thought that it is toxic to me. Some people could develop kidney stones, but that information is also from the internet. My kidneys still function.
My Oncologist, one involved in LU-177 SPLASH Clinical Trial asked me to stop my IV-Vit C doses of 100g weekly because he said it would counter act my fight with mCRPC.
I never had any vit C infusion in my life and I don't believe that I could even be able to organise it. How did you get that infusion? I would recommend you to stop as per your doctor instructions.
I believe that during the clinical trials they are examining the lutetium and not the combination of vitamin C and lutetium.
They are using you during the clinical trials to find out about the effectiveness of lutetium and that is why they are paying for that trial.
I hope you understand that.
Therefore they are no clinical trials which could prove the combination of vit C and lutetium. I believe that during radiation or chemistry it is not recommended to take antioxidants like vitamin C or vitamin E etc.
During my early chemotherapy I went to the hospital pharmacy and they printed out for me some information from the MSKCC internet site about that. That was 5 years ago and I can't exactly remember everything but antioxidants are not recommended. I didn't take any vitamins during my early chemotherapy 6 cycles.
Always consult your doctor or pharmacist.
Intravenous Vit C? Very high dose?
I am only taking 2g vitamin C dose every so often maybe 1g per hour. 30 years ago I was buying slow release vitamin C but now I am taking the cheapest possible. Constantly during the day until I get bored.
I belive it is enough to take 1g per hour for 5 hours.
This review may also be helpful, in supporting use of Vit C. (but its way over my head) pubmed.ncbi.nlm.nih.gov/333...
Targeting a single enzyme can kill prostate cancer cells
The importance of training your legs (if you can, of course)
Abiraterone and Enzalutamide Raise Metabolic, Cardiovascular Adverse Event Risks
Thymoquinone (found in negella sativa and monarda fistulosa plants) may target some castration resistant and/or metastatic prostate cancers
Immunosuppresion in cancer microenvironment
