Any advice on LU 177?

[Russ506]

I don't know if I'll be a candidate for the procedure because of kidney issues, but I still want to make an informed decision between that and risk bone pain from BAT. My MO is pushing for LU 177 if possible.

I want to continue living for as long as possible, not just breathing as long as my body will let me. Can anyone please share their experience with LU 177and, if allowed, their experience with bone pain and BAT?

[GP24]

You can get Pluvicto with one kidney only or even no kidneys any more. It should be avoided if there is a kidney blockage. Then Lu177 will stay in the kidney for too long and may cause damage to the kidney.

[Russ506 in reply to GP24]

Thanks.

[Tall_Allen]

Be sure to get an FDG PET/CT in addition to a PSMA PET/CT.

BAT doesn't increase survival in trials so far. It only delays progression with enzalutamide.

[Russ506 in reply to Tall_Allen]

Thanks.

[docbulldog in reply to Tall_Allen]

could I get some help on what a FDG PET/CT scan would be? I haven’t had a scan since I was dropped out of the LU 177 program in January after 3 infusions.

if it’s a very sophisticated scan, I doubt if my local radiology center has on.

Thank you!

[Tall_Allen in reply to docbulldog]

It's the most popular PET scan there is.

[HopingForTheBest1 in reply to Tall_Allen]

My oncologist told me I am better off being able to compare more recent/multiple whole body bone and CT chest/abdomen/pelvis scans that I have had, than FDG and PSMA scans that I had one time each several years ago.

[Tall_Allen in reply to HopingForTheBest1]

That is true. Why were you interested in FDG PET scans?

[lowT163]

only experience I’m personally aware of is that it can be contaminated so get it at a very qualified facility.

[Russ506 in reply to lowT163]

Thank you.

[Pwjpp55]

I completed all 6 in March. My end PSA was 0.07. Outside of feeling "unwell" for a few days afterward, I had no side effects. If you qualify, I recommend it!

[Russ506 in reply to Pwjpp55]

Thanks!

[Dave78717]

I did it in India, flew there 3 times. It can help. Some other people I know in very bad shape got a lot of help from it. (This was a person who discovered he had PC when his PSA was like 1000 and it had already spread everywhere.) It really helped him.

I have no idea what to say regarding kidney issues. I wanted a cure it didn't do that just stopped progression for a year, but another person I know, it seemed to have cured him. He was in relatively early stages of the disease.

I'm doing something alternative now, that, while I won't recommend because I am still evaluating it, if you are seeing your options close down around you and you care about QOL its worth considering. Message me.

[Russ506 in reply to Dave78717]

Thank you.

[Brbnbrn]

I will let you know! 1st infusion of Pluvicto is this Friday at University of Michigan. Kidney function at 43% as of last Friday. All is a "green light" as of now! (BTW PSA at diagnosis in 2017 was over 1,200 & sits in mid 40's now.)

[Russ506 in reply to Brbnbrn]

Thanks. Good luck!

[LongTimeRunning]

I've had one infusion, 2nd coming up in a few weeks. My mouth was a bit dry, but otherwise no direct side effects from the treatment. An ancillary side effect was going to the bathroom almost every hour (including the first night) for the first 24 hours to flush out the lutetium (drinking lots of fluids) as per recommendation by doc so that it doesn't build up in the kidneys, so crappy sleep for a night or so. There is trace radiation in the body for a few weeks, but not at harmful levels.

I also noticed the guy administering it didn't seem overly concerned about being in proximity to me while I was there.

[Russ506 in reply to LongTimeRunning]

Thank you.