Breaking teeth

[runtrails]

Recently I have had a couple of molars break off . I've only had a treatment of Lupron for 6 months . Two each 3-month injections. Could this be related to the Lupron along with the other side effects I have enjoyed like hot flashes, fatigue, muscle pain, and weight gain or just coincidental?

[mrscruffy]

After 6 years and 10 months I had to have all my top teeth removed.

[E2-Guy in reply to mrscruffy]

So sorry to hear this!

[Jeremiad53 in reply to mrscruffy]

I have been at this battle for 76 months , and my teeth are falling apart. How can I get teeth pulled when I am doing Zometa?

[Kaliber]

After 54 months of Lupron - Xtandi, I have two molars broken off mostly at the gum line ( OK since they were root canals ) and a couple front teeth with new cracks or little pieces missing. Teeth were perfect before I started ADT. They still function and I eat with them just fine. No biggie . Not worth the thousands to get every thing fixed properly.

[E2-Guy in reply to Kaliber]

Sorry Bro!

[Kaliber in reply to E2-Guy]

❤️❤️❤️

[mrscruffy in reply to Kaliber]

Got too many women to not have near perfect teeth. Peer pressure is a bitch, especially from the ladies

[Kaliber in reply to mrscruffy]

yayahahahaya yayahahahaya. I love it, man you live in a way different aPCa world than I wished I did. I can only imagine / dream thinking about things like my appearance and those fine ladies like you can. I get so much Zometa that “ any “ mandible work would be sure necrosis and metal plate implant. I hate dental work anyway. I’m envious… maybe if I got some skin wrinkle cream and lost a couple of pounds … dunno. Maybe a tux would spruce up my appearance. Just say’in Yayahahahaya.

❤️❤️❤️

Oh well ..

[mrscruffy in reply to Kaliber]

All my "wives"

.

[Kaliber in reply to mrscruffy]

yayahahahaya yayahahahaya. Well I’d be impressed. Do you live in Utah , just wondering 😂😂😂😂. I’ve had 5 of them but one at a time, more or less. Married to this one 45 years now.

❤️❤️❤️

[mrscruffy in reply to Kaliber]

The one on the left is my wife the others my wife calls the "other wives" hahahah. Left to right 62, 52, 31 and 39. Good looking old broads. All worked for me at one time.

[Kaliber in reply to mrscruffy]

great looking crew gathered around their great looking guy. It’s all good, looks like everyone was having fun. Pretty kewl.

😁😁😁

[timotur]

It most likely is related to Lupron, one of its many SE's.

ADT causes increased osteoclastic activity,6 bone resorption,7 bone loss8 and an increased risk of fracture.9 The rates of bone loss are 2% to 8% in the lumbar spine region and 1.8% to 6.5% in the femoral neck during the initial 12 months of continuous ADT.2,6.

Periodontal disease results in resorption of alveolar bone and loss of the soft tissue attachment to the tooth.

ncbi.nlm.nih.gov/pmc/articl...

hormonesmatter.com/lupron-s...

[Derf4223]

I just consulted with Dr. Google and Lupron, Prednisone, Prolia -- all list possible dental problems as LT SE's. Of course our dental health declines with advanced age too.

[Echotango51]

I have been on lupron since 2016, every 3 months. My Doc did a bone density test April 2022, they put me on Alendronate Sodium 70mg to help on my bone lost. Maybe check with your Doctor about that.

[Kaliber in reply to Echotango51]

Roger that, de Novemberlimazulu -ttr. 64C, Creech

[Ian99]

I have been on Zoladex for almost 2 years, and Zytiga. To help the bones I take AdCal-D3 twice daily. Also Alendronic acid following a Dexa scan showing ostopenia (-1.3 in femur). So far no problem. Good luck.

[GMorz]

I am a dentist is Australia. Certainly the bone surrounding teeth can be affected and more prone to periodontal disease but it will not make the tooth weaker according to most literature . However the drug can affect the oral environment as with aging process so mouth is dryer and more acidic and making teeth more vulnerable to decay and breakdown/ erosion/ attrition of teeth.

Try to stimulate saliva with sugar free gum and artificial saliva like biotene helps enormously.

Use Tooth mousse by GC as a dental tooth paste also remineralises the teeth

[MrG68 in reply to GMorz]

After 6 months with 2 injections?? Wow, that's pretty rapid.

[GMorz in reply to MrG68]

no will not be from the injections is what I am trying to say.

[Cancerfighter10 in reply to GMorz]

Thank you Dr. !!

[London441]

That’s the first advice by a dentist I’ve read on the subject, thank you. All I know is like everything else, we also have to be fastidious about dental health as we age, regardless of disease, treatments etc.

[Ol19]

My husband suffered with gum disease years before his diagnosis of advanced prostate cancer. On his diagnosis tests revealed he had low testerone. I believe his gum issues were a red danger flag for prostate cance but we were in the dark about it back then as no routine checks for men in the UK.

His teeth although crowded are ok, it's his gums that are the problem!

[lcfcpolo]

Good timing this. On Enzalutamide for almost 3 years and tooth just broke off earlier this week. I'm in the UK and my local prostate support group leaflet recommends using a toothpaste called 'Duraphat 5000'. This is prescription only though from the dentist. Advanced prostate cancer just keeps on giving and giving.

[anonymoose2]

I’m the same teeth getting damaged beyond the norm. Getting them pulled and going dentures is my logic at this point.

Ive been looking at it this way after 5+ years on ADT. The repercussions from the therapy is stressful and I me personally have found stress is making me grind my teeth. Think about are you relaxed when going though a horrific hot flash? I’m sure not. I say some nasty words sometimes and generally find myself biting the bullet you might say all hard on the teeth. I’m surprised the dentist didn’t bring this up.

I’m no dentist but thinking at least a teeth guard at night would be helpful. If someone told me 5 years ago the stress would cause possible teeth grinding it might of stopped me from getting dentures.

[Helmit]

Nonsense. Usually teeth break off because of neglect. Once a tooth is formed and erupted, only oral environmental factors can cause breakage. Decay due to dry mouth, xerostomia, poor oral hygiene and unrestored teeth after root canals, Endodontic treatment. Regular preventive Dental care in the Dental office would eliminate most tooth fractures.However periodontal disease is also the result, in most cases, due to poor oral hygiene, poor care in the Dental office, yes that happens. Bone loss can result from Lupron etc and usually a bisphosphonate, ie. Prolia, Xgeva etc. are given with 3 month Lupron Depot, or Eligard, to prevent bone loss and pain. Also Calcium+D3 will help bone strength. EXERCISE is a must.

When the bisphosphonates are given IV, Osteonecrosis of the jaw can result in a small % of Oral Surgery procedures. Patients are given that information before procedures.

It is advisable to have all Dental care done before taking the Bisphosphonates. Bisphosphonates slow down the Osteclastic process. A constant change in bone is always occurring. Osteoblasts lay down new bone while Osteoclasts take bone away. Hope this info is valuable. D.D.S.

²

[Jeremiad53 in reply to Helmit]

Teeth break, they wear down, it is not the fault of the person. I have 3 molars out of four that are worn down to the level that I can feel it with my tongue or finger, but there is no pain yet. It is like someone sanded the last half of them off from chewing.

[runtrails]

All good information. Interesting on the dry mouth as oxybutynin that I take for the hot flashes makes my mouth really dry. And I definitely have been grinding my teeth more or at least clenching them.

[Miccoman in reply to runtrails]

Oxybutynin for hot flashes? No matter why you are taking this antimuscarinic, you really, really need to know about this from the NIH (emphasis mine):

"As far as bladder medications are concerned, immediate release oxybutynin has been shown to adversely affect cognition in the cognitively intact elderly. The newer antimuscarinics for OAB – darifenacin, fesoterodine, solifenacin, tolterodine, and the quaternary ammonium compound, trospium chloride – do not appear to adversely affect cognition. Oxybutynin transdermal gel similarly appears to have no demonstrable adverse effect on cognition."

and

"It is well-established that the use of medications with antimuscarinic properties (e.g., antidepressants, antipsychotics) is associated with impairment of cognition in community-dwelling older people. Cholinergic mechanisms are implicated in the neuropathology of Alzheimer’s disease and the continued use of anticholinergic medication over a four-year period appears to be associated with cognitive impairment and an increased risk of incident dementia."

For the entire article see: ncbi.nlm.nih.gov/pmc/articl...

Of course your doctor will probably discount this -- every urologist I've met has -- but you need to be the one who makes the informed decision on medications that the National Institutes of Health say can "adversely affect cognition in the cognitively intact elderly."

[E2-Guy]

F-ing Lupron jabs! I highly recommend E2 gel! Only side effect is little boobs.

I refuse to subject myself to those nasty chemical injections!

[Jac_J in reply to E2-Guy]

on the E patches last few months and doing fine. So far.

[NotDFL]

Because the molar breaks happened after only six months of ADT, I doubt that there's a causal relationship. More likely, these molars were likely to fail anyway.

A thorough dental exam might be in order to (hopefully) prevent further problems.

[runtrails in reply to NotDFL]

Makes sense..dental apt is made. 6 months of fatigue, hot flashes, shrinkage below the belt, addage above, and all that, seems like an eternity. Not sure how all you warriors have done years.

[Sandy752]

I've been on Lupron more than 9 years and had two molars pulled in the past 18 months. Dentist felt that two teeth, both of which had root canals many years ago, (I'm 78) just wore out over time. I am having crowns put on two of the middle bottom teeth which are getting a lot of wear because I am using those cutter teeth as chewers with the two bottom molars gone.

[SteveTheJ]

I'm not aware of that being a result of ADT but I could be wrong. After 3+ years all my teeth are intact. What you have to be aware of though if you go on any bone-strengthening medications, you should first have all known dental work done because necrosis can result from the dental work.

[Fiddler2004]

4 Molars gone in 4 years and a 5th one on the way, after spending $5K trying to keep up I'm done. 😟 started after my 1st treatment with Zometa, discontinued the Zometa now just Lurpon/Xtandi combo, coming up on year 4 , they're cracking off , mostly at the base. Seems similar to others description here.

[Jac_J]

I use a mouth guard on top and bottom teeth. After 2 years on Eligard my teeth (and bone density) are still very good. A Periodontist I used to see told me years ago he sleeps with a mouth guard. At the time I thought that was overly cautious. I now think he is overly smart. I personally consider it irresponsible to not use a mouth guard now.

[runtrails in reply to Jac_J]

The mouth guard is a good idea and interesting. Sleep is also interesting. Not sure I remember what that is. Melatonin, sleep aids, soothing music, nothing really gets me more than an hour and a half sometimes 2 hours. Even with medicines to help with the intensity of the hot flashes The Hot Flashes wake me up. But I seem to have adapted to limited continuous sleep.. And at least for now they've only got me on this 6 month ADT treatment post surgery and radiation so maybe all that will start to get better over the next few months.

[Jac_J in reply to runtrails]

I urinate every 2 hours so sleep for me is an interrupted 6 - 7 hours.

Try three mouth guard much much better than the alternative

[j-o-h-n]

Must I be the only one to defend the Tooth Fairy?

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 05/19/2023 9:20 PM DST

[Kaliber in reply to j-o-h-n]

takes one to know one … big guy. 😂😂😂😂

[j-o-h-n in reply to Kaliber]

Hehehe........ come closer dearie I'd like to hit you with my pocketbook....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 05/20/2023 7:05 PM DST

[Kaliber in reply to j-o-h-n]

well ….. how much money is sticking out of it …. Just say’in 😂😂😂

[j-o-h-n in reply to Kaliber]

You know, the usual $2.00 discounted price you charge us special clients.....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 05/20/2023 10:30 PM DST

[Kaliber in reply to j-o-h-n]

not $2.00 …. It’s was 2 bits … that’s $.25 …😂😂😂😂

[j-o-h-n in reply to Kaliber]

"Shave and hormones 2 big tits"....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/21/2023 1:58 PM DST

[Kaliber in reply to j-o-h-n]

yayahahahaya yayahahahaya …. That’s a good one bruddha. Ain’t that the truth tho.

Hope you are comfortable today and having a nice weekend big guy.

❤️❤️❤️

[j-o-h-n in reply to Kaliber]

I am comfortable thank you.....I'm finally texting all my friends.....now all I need is a cellphone......(You have a good one too - look out for the text it will be on the way).

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/21/2023 4:47 PM DST

[Kaliber in reply to j-o-h-n]

it’s better without the phone, texting can be expensive depending upon the plan you have.

❤️❤️❤️

[j-o-h-n in reply to Kaliber]

Thanks for the info................... back to the tin cans and waxed string...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/21/2023 10:40 PM DST

[Kaliber in reply to j-o-h-n]

lol ❤️❤️❤️

[j-o-h-n in reply to Kaliber]

Thank you... BTW Currently I have a company installing laugh meters in every member's location and the results of those meters will report to me electronically....If they don't laugh at my posts, I will deduct $2.00 from their current month's social security payment. All monies collected will be deposited in my private charitable account.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 05/22/2023 6:03 PM DST

[CAMPSOUPS in reply to j-o-h-n]

5 days and were still breaking teeth. Let's' break some bread instead !

[runtrails in reply to CAMPSOUPS]

For sure..

[CAMPSOUPS in reply to runtrails]

I thought of that when I saw the subject line of your post again in the main page lol.

[j-o-h-n in reply to CAMPSOUPS]

google.com/search?q=breakin...

I got first dibs on the heal...............

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 05/22/2023 10:16 PM DST