Peter Attia’s new book

[Scout4answers]

has a chapter on Cancer (10% of book)

his thought is that cancer may best be treated as a metabolic disease.

Also he thinks immunotherapy shows great promise.

well worth the read

[dockam]

Sweet and Mahalo for posting, just got the Audible version to listen on my hikes

amazon.com/gp/product/B0B64...

[tango65]

How does he propose to treat cancer?

[Scout4answers in reply to tango65]

He is mostly focused on how to prevent cancer and have a long "healthspan". We have not read the rest of the book yet so I can't address how he proposes to achieve a long "healthspan", but suspect it is through diet and exercise. Here is an excerpt:

[tango65 in reply to Scout4answers]

Thanks

[Scout4answers]

more

[NickJoy]

Thank you for posting - very interesting book

[Purple-Bike]

Peter Attia makes deep dives, he is a wealth of knowledge. Several other chapters are worth reading too. E.g. on heart. A combo statin + a so-called PCSK9 inhibitor will drastically reduce the risk of getting cardiovascular disease. More details on his show notes and blog.

[Scout4answers in reply to Purple-Bike]

Have not read that chapter yet is a PCSK9 inhibitor available OTC?

[MateoBeach in reply to Scout4answers]

There are two FDA approved PDSK9 inhibitors. Monoclonal antibodies that must be injected. Very expensive and not OTC. They are indeed the best drugs to lower ApoB and LDL cholesterol for those whose lipids are not adequately controlled on maximal tolerated doses of statins.

Peter Attia is much more an expert on this (than he is on cancer). Many good podcasts for subscribers (The Drive). Many also available on YouTube for free. Some of his perspectives are naïve and self-centered. But we can forgive him that, in that he is not yet 50 and doesn’t yet know how things change (like exercise capacity) after 70+, much less while on ADT and other treatments we deal with. He does do deep interviews with some excellent sources so I find it worthwhile.

[MateoBeach in reply to MateoBeach]

mayoclinic.org/medical-prof...

[Scout4answers in reply to MateoBeach]

we are both going to get an APoB test.

Are you saying that increasing statin dose may work in lieu of a PDSK9 inhibitor.

Attia seems to advocate for using both together.

[MateoBeach in reply to Scout4answers]

As you know, Attia is very aggressive with lipid control for cardiovascular risk management. And we start with higher risk profile due to being older, male, and the effects of ADT with APC. Any other personal risk factors? I also have positive family history for CVD and have high coronary calcium score and High BP (controlled). That is why I have been on maximum dose of statin (80mg atorvastatin) for 30+ years. My lipids are actually excellent from that and my apoB is 60 which is good. So I probably don't need to add a PCSK9 inhibitor, even though that could take my apoB down even further to 30-40ish. If I went to Peter's clinic he would probably have me on it. But my PCP won't since my lipid numbers are all considered excellent. For you (knowing some of your history) probably an apoB of around 60 or under would be a good target.

So this is an individualized assessment based on one's risk factors and history. And how well controlled they are, or can be on statins at maximal tolerated dose. Statins have additional benefits including anti-inflammatory and appears to retard PC progression. Keep on Scouting, and dancing. Paul

[Purple-Bike in reply to Scout4answers]

Statins and the inhibitor on average each have about the same effect on apoB. It's the combo that gets the level all the way down to minimal cvd risk. There is only a single paragraph in Attia"s book on the PCSK9 inhibitor. A more detailed and compelling story is given in his show/blog notes, 20 dollars per month 150 per year.

On pitavastatin I got my apoB down from from 86 to 65 after four months, but will give it a little more time to see if it goes further down before making a decision on the inhibitor. As MB says, It's expensive, but I would love having it down to 30 or so although somewhat diminishing returns set in the lower the number you get. Attia says you get the biggest boost with the first 50 % reduction in apoB.

[Purple-Bike in reply to Purple-Bike]

To avoid the major hassle of injections and the high cost of the PCSK9 inhibitor, Ezetimibe could be an option of getting down apoB if one wants to go further than the statin alone. Still pricey, but less so. One has to check liver values.

[Purple-Bike]

No. India or Brazil are the places I know. May need to be injected. Apparently almost no side effects. Am searching for a supplier. Alldaychemist does not have it.

[Gl448]

Which doctor did you recently read?

Cutting sugar is always a healthy choice, but prostate cancer is not fueled by sugar/glucose.

[Gl448]

Was that directed at my question about which doctor you recently read? Why so touchy? I asked for the name of an author, not for you to explain anything...but hey, if you want to be so overly sensitive, more power to you.

My mind isn't set; it can be changed, but the current standard for PCa is it's not sugar fed. I'd love to see some real evidence from real doctors to the contrary if exists.

[Gl448]

The QOL post?

That was satire. Too bad it went over many people’s head.

I’m not off of SOC. I’m not a fool. I’m also not (yet) as desperate for unproven “it might work” non-scientific treatments as some.

You still haven’t said which doctor you were reading that said cancer is metabolic disease and curing sugar is the cure.

I’m just curious…not looking to attack him in this thread.

[Scout4answers in reply to Gl448]

sarcasm is tough to pull of on a message board

[Gl448 in reply to Scout4answers]

indeed. Easily missed when intended, and often non-sarcasm is taken as sarcasm.

Although I ended that post with tongue planted in cheek, indicating not to be taken seriously

Cheers.

[Gl448]

🤣🤣🤣🤣🤣

Nothing I say is worthwhile because I haven’t been in remission for 7 years?

The only thing I said was sugar is not the fuel for PCa. That’s a fact whoever says it until there’s peer reviewed studies showing otherwise.

I’ll go with science before opinion of people selling alternative books or programs.

(Oh, you deleted your reply…)

[FlyJ]

I have just finished Attia's "Outlive". It is a very good read. I have been a long time listener to his podcasts which are a deep treasure grove of good information.

The book describes "the four horsemen": Cardiovascular disease, Cancer, Neurodegenerative diseases (dementias), and Type 2 diabetes and it's precursor self: metabolic syndrome as the four most common pathways leading to our eternal home.

He describes four powerful weapons that we have to increase healthspan/lifespan: Exercise, nutrition, sleep, and emotional health. These he goes into great detail as part of his "medicine 3.0 " which is to prevent/treat early vs. our current"medicine 2.0" : treat the problem once it has been long established.

What I found as the most personal and powerful part of the book is Peter's struggle with his own emotional health and how that has affected his life. To me the poignant message was his learning "how to live" instead of worrying about "how to avoid dying" (his strong family hx of cardiac disease).

I have found this to be my struggle too as I spend hours and hours researching and reading about PCa and it's treatment at the expense of "living" and my most important relationships.

[Scout4answers in reply to FlyJ]

thanks for sharing. Awareness is the first step towards change. Hope you will join the QOL warriors here and enjoy what time you have left on the planet. PCa was a wake-up call for me.

Focus on fun with those you love in what ever way you define it.