No Benefit With Longer Course of ADT in Localized, High-RiskProstate Cancer

[ADTMan]

renalandurologynews.com/hom...

[PSAed]

Thank you for posting this.

I hope I am interpreting this incorrectly, but does this mean that men who were treated for 24 months or more with ADT + EBRT and suffered penis shrinkage plus the other usual multi side effects, done so unnecessarily?

I believe (at least in my case) the shrinkage occurs after 18 months or more of ADT plus RT . I was on LUPRON for 24 months + 39 fractions of EBRT 78 Gys.

[tango65 in reply to PSAed]

The patients in the study also had a brachytherapy boost added to the radiation of the prostate.

[ADTMan in reply to PSAed]

Unfortunately, it looks that way.

[timotur]

Yep, had HDR-BT plus 18 months ADT and it seems the last six months did the most damage.

[PSAed in reply to timotur]

I'm of the same opinion. Now it seems it wasn't even necessary, and every time I go to the toilet I'll be reminded of it!

[MateoBeach]

Looks like good news to me: Approaching 90% had no BCR nor death after 9 years follow up. And can stop ADT at six months.

[OldVTGuy]

Thanks for sharing. A very important study indeed. Like many others, I am a G9 with a localized disease. Have 2 months of ADT behind me and am about to start 44 sessions of IMRT. The plan is for 24 months of ADT but if my numbers are good I will be thinking hard about lobbying for less.

[ADTMan in reply to OldVTGuy]

I think it's important to note that treatment consisted of IMRT and brachytherapy boost. The brachytherapy boost can be low dose rate brachytherapy or high dose rate brachytherapy. I would also like to know what the definition of "localized" is in this study.

[KAgolf]

wonder how this would compare with Proton with a boost?