confused: Did psma and did not show... - Advanced Prostate...

Advanced Prostate Cancer

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confused

Moco1 profile image
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Did psma and did not show anything although psa rose.

Then 4 months later took body fdg pet/ct scan and showed lung rose 1.7 to 1.8 in 4 months and mild FDG uptake in other areas.

Dr’s will meet tomorrow if big enough to take biopsies anywhere.

They feel its from prostate and will see after taking Lupron if areas shrink. I did surgery 4 years ago then a year later radiation..

Doesn’t make sense it didn’t show on psma unless its a secondary cancer?

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Moco1
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Tall_Allen profile image
Tall_Allen

Not all prostate cancer expresses PSMA, even metastases in the same person. Expression of PSMA can be "heterogeneous" within individual tumors or "discordant" when some tumors express PSMA and some don't. You can read about it in this article:

prostatecancer.news/2019/12...

MichaelDD profile image
MichaelDD

You haven't given us much history on you in your bio. And reading what you have doesn't give much of an idea either. So do you have a low PSA, and they are saying this is in your lungs or lung?

fmenninger profile image
fmenninger

I have read that over 80% of pca is detected on psma pet scan. Does that mean approx 20% is non psma avid? As we all know psa is a bio marker for psa avid pca. Not all pca is both psma and psa avid other ways the psa would go hand in hand with psma pet scan. For example, if you had a psa of 5, what would you expect on a psma pet scan vs a psa of 1000? Most likely, the higher the psa the more lesions seen on a psma pet scan but can you truly quantify and correlate the two? I think more research needs to be done. Thoughts?

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