Not all prostate cancer expresses PSMA, even metastases in the same person. Expression of PSMA can be "heterogeneous" within individual tumors or "discordant" when some tumors express PSMA and some don't. You can read about it in this article:
You haven't given us much history on you in your bio. And reading what you have doesn't give much of an idea either. So do you have a low PSA, and they are saying this is in your lungs or lung?
I have read that over 80% of pca is detected on psma pet scan. Does that mean approx 20% is non psma avid? As we all know psa is a bio marker for psa avid pca. Not all pca is both psma and psa avid other ways the psa would go hand in hand with psma pet scan. For example, if you had a psa of 5, what would you expect on a psma pet scan vs a psa of 1000? Most likely, the higher the psa the more lesions seen on a psma pet scan but can you truly quantify and correlate the two? I think more research needs to be done. Thoughts?
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