worried

[Chris52981]

Are there still many options after being metastatic and now Zytiga and possibly xtandi failed- did this happen to anyone and now doing well? Also did anyone have psa ever go up on xtandi and scans showed in remission - ( does have prostate )

[Tall_Allen]

Many options depending on his situation. Also, many clinical trials.

[Chris52981 in reply to Tall_Allen]

thank you - do you know if a psa can go from .60 to 1.2 in three months - last time

He was on Zytiga cat scan showed no new mets

[Chris52981 in reply to Chris52981]

sorry while on Xtandi with a prostate - with out calling Xtandi a failure

[Tall_Allen in reply to Chris52981]

They usually want to see more/bigger metastases before they give up on it

[Chris52981 in reply to Tall_Allen]

ok then they prolly should have kept him on Zytiga cause there were no new metastasis just a little change in the ones he currently had

[BrentW in reply to Tall_Allen]

I am in a similar situation, just waiting for the Xtandi to fail. I am filled with dread when I read of clinical trials being a way forward. That implies that tried and proven treatment options are few. Please tell me I am wrong.

[Mw921000000 in reply to BrentW]

I feel the same way And hope someone disagrees with us. I feel like clinical trials are last resort. I’m praying xtandi works for a long time.

[Tall_Allen in reply to BrentW]

As I said, many options for mCRPC in the US - but fewer in the UK. Aside from abi and enza, these options are currently approved for various indications: docetaxel, cabazitaxel, Provenge, Xofigo, Pluvicto, 3 PARP inhibitors + abi/enza (maybe as of this month). Clinical trials are ongoing for several drugs used earlier, and for combinations one wouldn't ordinarily get.

[Chris52981 in reply to Tall_Allen]

if my dad psa went up on Zytiga but in the cat scan there was minimal change and the change there was - was in previous Mets- does that necessarily mean the med was not working-

[Chris52981 in reply to Chris52981]

now on xtandi and it went up again but is it possible that 1.2 is still Low and maybe xtandi is working since he still has a prostate?

[Tall_Allen in reply to Chris52981]

Yes, PSA is still low.

[Chris52981 in reply to Tall_Allen]

it was .60 and doubled so I wasn't sure if it can fluctuate or to that much

[Chris52981 in reply to Tall_Allen]

also thank you for quick response

[Boywonder56]

That doubled in 3 months so you would check it again I guess in 3 months and if it goes to 2.4 there's a possibly a problem sometimes it jumps and goes back down just my two cents

[Chris52981]

they are going to do a PSMA scan- do I guess that's be cautious

[Hidden]

Xtandi helped for a couple years for my husband. Switched to apalutamide, but that also failed big time. PSA kept going up. Scans showed some improvement on a few mets, but increase in many other areas. As you will see from the replies there are still options for you. Every treatment varies in success for everone. There is a lot to consider when determining treatments and your doctor know your case best. What worked for one case may not for another. Of course, ask your doctor why he recommends one treatment over another, he has his reasons. Our doctors always explained why they chose one over another.

[Hidden]

Exactly where we are. Starting Pluvicto this month.

[rkc47]

I went through Xtandi and then Zytiga. My PSA climbed to 40ish and I went through chemo with Jevtana every three weeks for a year. PSA got to around a hundred. I was then given six monthly injections of Xofigo (radium 223), which ended about a month ago. My last PSA back then was 338. I am back on Zytiga and now lynzarza. I do not have a recent PSA. I have tolorated all of my treatments very well. My only complaint is being fatigued. I meet with my oncologist in a couple weeks to see what's next. My radiation oncologist is setting up a consultation with Barnes about another radium isotope. I have been continuously treated for 20 years...Lupron surgery, radiation, etc.