Thanks very much to everyone for replying to my earlier post but the core question that I now have is;
Since my PSA is slowly rising (April 2.01 - Aug 6.6), should I switch from my current low dosage of 250mg Abiraterone with low fat meal to the FULL dosage of 1000mg Abiraterone WITHOUT food, to see if this will help lower my PSA?
Comments and advice would be much appreciated.
That's the same dose. The fat increases the biological absorption so you can save money by taking fewer pills.
Can you indicate some literature on this low dosage, so I can understand how much food to take with it ? Thank you.
Now that the generic is available, it is best to take 1000 mg/day without food.
Doesn't extending the dose with fat add a level of unpredictable dosing?
Or is there a proven way to compensate for that with a specific calibrated meal?
It's going to be different in every man. Unless one does blood tests everyday to check on one's plasma levels. That's why it's safest to take 1000 mg/day fasting.
>slowly rising (April 2.01 - Aug 6.6)
Tripled in ~ 3 months ? I would say its rising pretty fast.
oh oh. well going to try 1000mg on empty stomach. Got nothing to lose. thanks for your comment
It's worth a try... It's hard to know what your individual absortion rate of abiraterone is, and other facors like amount of fat in the yogurt, etc.
Be your own guide. Listen to your body, PSA, and Scans, and see if it works. We have all been told that when one ADT stops working, switching it up doesnt last for long. But try. We seem to be one big human experiment anyway. What was SOC last year gets tweaked and changed this year.
Aspirin is good. Aspirin is bad. Coffee is good Coffee is bad. Do Docetaxel upfront at Diagnosis, use Docetaxel to reinvigorate ADT to become Sensitive again. Use SBRT for bone pain, use SBRT to primary tumor if Oligometastatic in Prostate to extend OS. Everything is moving and every man responds differently, so give it a try! Try everything to delay Hormone Failure and delay Hormone Resistance. Mike
Exactly. what's the worse that can happen. Starting today on 1000mg on empty stomach and see where that takes me in 30 days time. Thanks for your input.
Have you thought about switching from prednisone to dexamethosone (decadron)? Many people get an extra 6 months from that. link.springer.com/article/1...
There is also an Abiraterone withdrawal syndrome, where the psa can fall if the ABI is discontinued. sciencedirect.com/science/a...
you could always try 250 mg with a high fat meal. Or 500 mg with a meal. All kinds of choices with pills.
Whatever you do, I'd check PSA and your metabolic blood panel frequently. Blood pressure as well.
Have your Testosterone tested. if it's zero it doesn't matter how much Abiraterone you take.
Why do you say that?
The objective of Abiraterone is to bring your Testosterone to 0. If your Testosterone is indeed 0 you are taking the right amount. Your PSA rising would indicate something else is going on independent of this.
I'm sorry, but it's more nuanced than this and I'm not going to be the best channel for explaining.
I don't think there is much harm in trying other than that it might delay you moving to an effective treatment sooner. As others have suggested, I would try it for just one month and check PSA.
Agree with those encouraging you to go with standard dose. Counting on food to give you stable pharmacokinetics of absorption from day to day is probably fallacy except under tightly controlled conditions.
Should I continue Abiraterone for 12 months, or switch to chemotherapy now?
Hesitation before switching from Abiraterone to some other protocol. 
Abiraterone and Breathlessness
Switch to generic Zytiga
