Nebequa has stopped working after 11 months Now what?.

[DeanNelson]

Hi Gents,

Well, it's been a crazy 4 years, I remember when I first posted on here. I think membership was under 3K here I think it is like 16k now

I believe my treatment options are running out. I had my 3rd channel TURP on 9/21/2021 and put on Nebuqa due to a reaction to docetaxel. Fast forward 11 months I've had to have another channel TURP, the pathology report was back as more cancer growing

I have no idea what next.

Has anyone else failed Nubequa?

[joeguy]

I have been on Nubeqa for about a year, and it is starting to fail, with PSA increasing a little each blood draw. I hate to see it starting to fail because the side effects were far less than other ADT drugs. Also I am castrate resistant and metastatic, so I have been using it in a way that is not "approved".

[Longterm101]

Dean

What is your psa?

Where is the Metastasis/cancer showing?

Did u get a PSMA scan?

[DeanNelson in reply to Longterm101]

My PSA has never been over 3.6, Spine, ribs, lungs, bladder

NO

VA Care

[tango65 in reply to DeanNelson]

If you do not tolerate chemo, discuss applying to a clinical trial with Lu 177 PSMA, which is a systemic treatment (it will treat bone, lymph nodes and visceral metastases) and it has shown to prolong life.:

clinicaltrials.gov/ct2/show...

[Tall_Allen]

Lots of options: Jevtana, Xofigo, Pluvicto, Provenge, rechallenge with advanced hormonals, PARPi if BRCA+, many clinical trials

[wagscure259]

It appears that I am failing darolutamide whilst PSA remains low having risen from undetectable to .16 over past 6 months. Plan next is PSMA scan when PSA rises and then possibly radiate if oligometastatic Or trial of Lu-177 at MSK. I am chemo naïve.

[Longterm101]

Dean

What does your MO suggest for next steps?

[Blueslover]

Not yet fingers crossed. Been on it for 2 years