How long does Xtandi take to wash out of the body?

[Arthur479]

I know the half-life is 5.8 days +/-. But at what point does it get effectively low enough to say it is clinically ineffective?

I ask this, because I am starting with BAT after the Xtandi washes out. Since Xtandi blocks T from the cell membrane, I don't want to defeat the purpose of the HiT, lol.

[tango65]

Consult with your doctor.

I believe it is about 5 to 6 half lives and it may depend on the liver or renal functions.

ncbi.nlm.nih.gov/books/NBK5....

[Fightinghard]

My MO told me to stop Xtandi for at least 10 - 14 days to allow for wash-out before starting Pluvicto treatment

[Cynthgob in reply to Fightinghard]

But down in Tulane dr sarte is combining xtandi and Pluvicto. Something about the xtandi expresses the psma for the pluvicto to kill. Where are you getting the pluvicto?

[Fightinghard in reply to Cynthgob]

The Splash trial

[Shooter1]

I stopped Xtandi last week and start BAT on or around Aug. 10. Out of other options and Xtandi/Xofigo combo. has failed.

[Cynthgob in reply to Shooter1]

What it BAT??

[Hidden]

My husband's doctor said a washout period of 2 weeks (minimum) to 4 weeks is preferred. He went with 3 weeks mainly for scheduling purposes before he started his second round of BAT.

He had 10 high T injections until PSA spiked during his first round of BAT in 2021, then he went back on Xtandi for 8 months. He then started a second round of BAT and just had his 2nd high T injection last week.