Unprecedented Study Leaves Every Patient Cancer Free

[Steveo3312]

🙏 This can be applied to Prostate and other cancers.

dailywire.com/news/unpreced...

[6357axbz]

Hopeful. Thanks

[Faith1111]

What a hopeful piece of news. Definitely something to watch. Thank you for posting.

[pjoshea13]

Steve,

While mismatch repair–deficient mutations are not uncommon in colorectal cancer, this is not the case in PCa:

"Mismatch repair gene mutations are uncommon in advanced prostate cancer; however, in those harboring these alterations, immune checkpoint blockade can be effective. As such, assays that can accurately identify these men are critically important. Cell-free circulating tumor DNA-based sequencing approaches appear to be one viable approach for identifying these patients."

ncbi.nlm.nih.gov/pmc/articl...

-Patrick

[Faith1111 in reply to pjoshea13]

May be uncommon but still found in PC. My brother had mmr 2,3 and 6. Made him a good candidate for Keytruda.

[pjoshea13 in reply to Faith1111]

As the paper I cited says:

"assays that can accurately identify these men are critically important"

In today's NY Times article on the new study:

"These mutations occur in 4 percent of all cancer patients." Presumably less than 4% in PCa. (Smurtaw says 2%.)

I wonder how many of those know their mismatch repair–deficient mutations status?

-Patrick

[Faith1111 in reply to pjoshea13]

I wonder as well Patrick. Everyone should get their DNA tested for mutations.

[Magnus1964]

Thanks, great article.

[raisin123]

Bad article as they stated 18 but it was only 12 patients. They were also at stage 1 or stage 2 cancer so they didn't do the study on any stage 4 cancers which if it were really that great wouldn't they have included those?

[pjoshea13 in reply to raisin123]

As today's piece in the NY Times states:

"... a study of patients with locally advanced rectal cancer — tumors that had spread in the rectum and sometimes to the lymph nodes but not to other organs."