Swedish study - PCa gives increased risk of venous thrombosis

[Graham49]

Patrick has warned about this in his posts.

My doctors never mentioned it to me.

Epidemiology

Original research

Risk of venous thromboembolism in men with prostate cancer compared with men in the general population: a nationwide population-based cohort study in Sweden

orcid.org/0000-0002-5065-47... Balabanova1, Bahman Farahmand2, Hans Garmo3, Pär Stattin3, Gunnar Brobert2

Integrated Evidence Generation, Bayer AG, Berlin, Germany

Integrated Evidence Generation, Bayer AB, Stockholm, Sweden

School of Cancer and Pharmaceutical Sciences, Urology, Uppsala University, Uppsala, Sweden

Correspondence to Dr Yanina Balabanova; [e-mail]

Abstract

Objective To estimate the additional risk of venous thromboembolism (VTE) in men with prostate cancer compared with men without prostate cancer in Sweden.

Design Nationwide cohort study following 92 105 men with prostate cancer and 466 241 men without prostate cancer (comparison cohort) matched 5:1 by birth year and residential region.

Setting The male general population of Sweden (using the Nationwide Prostate Cancer data Base Sweden).

Primary and secondary outcome measures Crude incidence proportion ratios (IPRs) comparing the incidence of VTE in men with prostate cancer and men in the comparison cohort. Cox regression was used to calculate HRs for VTE adjusted for confounders.

Results 2955 men with prostate cancer and 9774 men in the comparison cohort experienced a first VTE during a median of 4.5 years’ follow-up. Deep vein thrombosis (DVT) accounted for 52% of VTE cases in both cohorts. Median time from start of follow-up to VTE was 2.5 years (IQR 0.9–4.7) in the prostate cancer cohort and 2.9 years (IQR 1.3–5.0) in the comparison cohort. Crude incidence rates of VTE per 1000 person-years were 6.54 (95% CI 6.31 to 6.78) in the prostate cancer cohort (n=2955 events) and 4.27 (95% CI 4.18 to 4.35) in the comparison cohort (n=9774 events). The IPR decreased from 2.53 (95% CI 2.26 to 2.83) at 6 months to 1.59 (95% CI 1.52 to 1.67) at 5 years’ follow-up. Adjusted HRs were 1.48 (95% CI 1.39 to 1.57) for DVT and 1.47 (95% CI 1.39 to 1.56) for pulmonary embolism after adjustment for patient characteristics.

Conclusions Swedish men with prostate cancer had a mean 50% increased risk of VTE during the 5 years following their cancer diagnosis compared with matched men free of prostate cancer. Physicians should be mindful of this marked increase in VTE risk in men with prostate cancer to help ensure timely diagnosis.

Data availability statement

Data are available upon reasonable request.

creativecommons.org/license...

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: creativecommons.org/license....

dx.doi.org/10.1136/bmjopen-...

[LearnAll]

Not just prostate cancer.. all cancers are "hypercoagulable" state which means there is increased tendency to clot formation and break up and become emboli ...which can circulate in blood and lodge in a organ. If in eye vessels, they can increase risk of blindness, in heart they can lead to heart attack, if in brain.. they can lead to stroke ,in kidneys..kidney infarction and so on.Natural blood thinners like Ginger, Turmeric, ,Onion garlic and green leafy vegetables can reduce the risk of thromboembolism. Frequent walking and physical activity allows better blood flow and can reduce risk of clot formation.

In some people, low dose aspirin(81 mg) or Nattokinase+serrapeptase may be needed. In high risk men, doctors might prescribe drugs like Warfarin (coumadin) with lab monitoring of extent of blood thinning.

[Bruce66]

This was never mentioned to me either by any of my doctors. Got hit with a DVT last Thanksgiving with both lungs FULL of blood clots. Put on Eloquis blood thinner for three months and now on baby aspirin daily as a prophylactic. Hope it works because I couldn't even take a deep breath without knives stabbing me in the back. Seems okay now but it was a wakeup call to get off my butt and move more.