If all else fails...

Phase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC). | Journal of Clinical Oncology

ascopubs.org/doi/abs/10.120...

[pjoshea13]

CAPE [caffeic acid phenethyl ester] from propolis is an AR degrader.

manukahealth.co.nz/en-nz/pr...

{"Certified to contain a minimum of 100mg of bioactives (flavonoids and caffeates including CAPE) per 2 capsules."}

"CAPE treatment suppressed the phosphorylation of Ser81 and Ser213 on AR, therefore decreased the stability of AR and induced degradation of AR protein in PCa cells"

researchgate.net/publicatio...

-Patrick

[Javelin18 in reply to pjoshea13]

Do you know of any trials using CAPE?

[pjoshea13 in reply to Javelin18]

No.

An interesting mouse study:

"This study aims at investigating the anti-tumor effect of caffeic acid phenethyl ester (CAPE) against animal carcinogenesis. In order to substantiate this fact implanted tumor Ehrlich carcinoma cells were assessed in vivo to Swiss mice strain. We found that administrating of CAPE (15 mg/kg S.C.) showed that the tumor volume decreased significantly by 51%. As a result, it improved animal chances of survival and they became healthier. An anti-angiogenic effect of CAPE in vivo was observed, as determined by a significant serum matrix metalloproteinase (MMP-9) reduction (142.1 ng/ml), activation of endostatin serum level (1.9 ng/ml), as well as DNA fragmentation in tumor treated mice when compared with untreated ones.

"Conclusion: CAPE has a significant inhibitory effect on tumor in vivo. This inhibition may be related to its angiostatic and apoptotic effects. It also reduced angiogenic factors which may shift the equilibrium to the angiostatic effect of CAPE. These findings provide the possibility for the future use of CAPE as tumor therapy in human clinical trials."

pubmed.ncbi.nlm.nih.gov/204...

see also: sci-hub.st/10.1007/s00210-0...

-Patrick

[j-o-h-n]

We use to say, take two and hit to left.........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/15/2022 7:19 PM DST