6357axbz

Thank-you TA. Very good info…

cesces

Dumb question, what is Pluvicto?

Woodstock82 in reply to cesces

Brand name for 177Lu-PSMA therapy. hcp.novartis.com/products/p...

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cesces in reply to Woodstock82

"Pylarify PSMA PET to qualify for Pluvicto (177Lu-PSMA617)"

Ok

May I ask what Pylarify is if Pluvicto is a psma pet scan?

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Tall_Allen in reply to cesces

Pluvicto (177Lu-PSMA617) is not a PET scan. It is a treatment for prostate cancer.

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cesces in reply to Woodstock82

May I ask what Pylarify is if Pluvicto is a psma pet scan contrast be agent?

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Tall_Allen in reply to cesces

Pylarify is a PSMA PET scan. Pluvicto is a treatment. To qualify for Pluvicto, one must demonstrate that one is PSMA-avid on a PSMA PET scan.

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Gabby643 in reply to Tall_Allen

Thanks again T A.

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Tall_Allen in reply to cesces

It helps if you read the post (end of first paragraph).

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Woodstock82

Good news! Glad to hear it. Thanks.

chickgreen

Thank you TA. I think I read that pluvicto is not being manufactured in the US because of some quality issues - do you know anything about that, and when they may start again?

Tall_Allen in reply to chickgreen

It is a global delay for at least 6 weeks.

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garyjp9

Thank you, TA

dougnola

That’s so exciting. Five years ago, I was one of the early folks who were newly diagnosed for whom insurance would cover abiraterone while still castrate sensitive. One day, I suspect I’ll need a next option so this is wonderful. Thanks, TA! ✌️ DougNOLA

jazj

@cesces Basically you can't use the Pluvicto treatment until you can see the cancer on a PSMA PET Scan because the Pylarify "tracer" drug they inject in you binds to PSMA. If nothing shows up on the scan, it doesn't mean you don't necessarily have active cancer, it's just not large enough to see on the scan. The Pluvicto binds to the cancer the same way as the Pylarify does. So there's nothing (or very little) for the Pluvicto to bind to if there's nothing on the Pylarify PSMA PET Scan. The good news is Pylarify is a little more sensitive than the older Ga68 PSMA so patients might be able to get the Pluvicto treatment a little earlier now.

@Tall_Bill Really appreciate all you do to keep people up to date. Hopefully Radioligand treatments like Pluvicto will be improved in the coming years as to date, it seems it significantly helps with impeding progression of distant metastases but unfortunately if I recall the time to cancer mortality was lengthened by an average of only 4 months. I believe the trial though was limited to people at a very late stage though? It seems like Radioligand and Immunotherapy are the areas we can look forward to further advancements and hopefully one day either there will be a cure, or, the disease can be managed indefinitely like HIV. The latter may come sooner than we might expect. I am anxious to see results from further trials where treatments like Pluvicto are used at the very first sign of PSMA PET detected recurrence.

MateoBeach in reply to jazj

Good post and clear views jazj. I am getting a novel form of Lu PSMA monoclonal antibody radioligand treatment tomorrow morning here in Perth where I flew yesterday to receive this. It is not in a trial. It is unproven and pre-trial as I am HSPC oligometastatic with all identified sites already treated with SBRT a month ago. Why am I doing this? I am preparing a post for later tonight to address that very question . I will be interesting your take. Regards. MateoBeach

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jazj in reply to MateoBeach

Read your post. I would do exactly the same thing in your situation. Takes some courage! But you could provide extremely valuable information on how patients responds doing Radioligand treatment earlier than later.

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KocoPr

Am I correct in assuming the Lu177PSMA617 pluvicto would still only be used for CRPC and not CSPC

Tall_Allen in reply to KocoPr

The problem in production is for the Lu-177 isotope. It doesn't matter what purpose it's used for.

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TJGuy in reply to KocoPr

Yes but clinical trials are in progress for CSPC. Results in one year.

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bobdc6

Thanks TA

Bob

nicecity

Thanks TA. Gave us very useful info.

j-o-h-n

pluvicto, A Walt Disney character (Pluto's twin).....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 05/12/2022 6:02 PM DST

TJGuy

The splash clinical trial, is using a competitor's similar product for PSMA therapy with reportably less side effects to saliva glands, kidneys.Over a year behind, but a competitor may help keep prices down, and avoid supply issues.