My 70 year old father has had urinary symptoms for a few years, was monitored with annual urology appointments and PSA tests. His PSA was slightly elevated this year for the first time so they finally decided to do an MRI. Results were, as far as I understand, not good. This will be confirmed in a biopsy but the scan showed almost certain cancer throughout prostate, seminal spread, lymph nodes, and masses in both femurs. I've read about metastatic PCa that reaches bones, but want to know what the very latest is.
All of that said, at the moment my father's symptoms are basically only have to pee a lot and associated discomfort. He is working, exercises fairly regularly for a man of his age (cycling). His PSA came in at around 7 (though the 4k test was around 75%). I wonder if any of this is relevant or not-super-high PSA is immaterial once it has likely spread so much.
I of course want to get my father the best care. He is otherwise very healthy. I am realistic about this, but want to be well informed. He is in NYC if that matters. Open to doctor suggestions.
To everyone else here, give you the best.
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nyc_son
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Right now, his first test should be a bone/scan CT, followed by a PSMA PET scan/CT. If he has distant metastases, he does not need a prostate biopsy. Take it one step at a time.
I think the biopsy is already in the works. Maybe can schedule the other tests separately — my sense was he needed them, and sooner rather than later. Interested to learn more but what you mentioned seem like primary goals to get across prior to treatment…
TA, Can you please explain why the bone scan should be done prior to the PSMA scan? I thought the PSMA shows everything and is much more sensitive in terms of seeing much smaller Lesions than the bone scan. I (and possibly others) am confused about this and would be grateful for help understanding. Thank you.
All of the major randomized clinical trials (RCTs) were done with a bone scan/CT before PSMA PET scans became available for staging. The STAMPEDE RCT showed that men with fewer than 4 distant metastases on a bone scan will have improved survival if the prostate is irradiated. So let's suppose you skip the bone scan and there are 6 metastases on a PMSA PET scan. Is prostate radiation still worth the side effects? Bone scans are cheap and easily scheduled.
There are guys on this board initially banged up far worse than your dad and have been around for quite a bit longer than google will lead you to believe! If your dad is also in nyc sloan kettering is a top notch place to go.
He has lots of treatment options (others i am sure will provide better advice than me as to what to expect).
Nothing against SK - but we didn't mesh well. They may be an excellent choice if you don't want to be burdened with making decisions on treatments.
Also highly thought of in NYC is Columbia/Presbyterian/Weill/Cornell (quite a mouthful - and it's two co-joined hospitals.) They are heavily involved in research and trials and have some really excellent people there. Just so you don't feel you only have one choice - I'd interview both and see which one fits best. SK tends to want everything done in-house and to their plans. Columbia/Presbyterian is a bit more flexible.
My wife was treated for a leiomyosarcoma at Columbia Presbyterian. I was treated for my PC (RP and SR) at Sloan Kettering. IMO, the contrast is stark. I would adamantly recommend MSK over Columbia Pres. I found the doctors and staff to be much more professional and organized and the physical facilities to be much cleaner and more modern at MSK. Also, many of the doctors at Columbia had originally trained at MSK.
The doctors I saw at Columbia/Presbyterian were primarily trained at John Hopkins. I suspect the experience there may depend on what cancer you're being treated for and what department is treating you. I was talking about the urology department and prostate-cancer since that seemed applicable in this discussion.
I could enumerate the issues I had with SK, but that might just have been a bad match between my expectations and their policies.
I will comment that at Columbia/Presbyterian I was treated by the top guys (department heads, chair of the department, research directors, etc., doctors who are frequently keynote speakers at conferences..) at MSK the only people I saw were residents. I did nothing special at Columbia to see these people, I went on their website, read their bios, and made an appointment. I wasn't given that choice at MSK, I was paired up with whoever they decided I would see.
MSK did have nicer waiting rooms. For treatment rooms, both seemed outstanding.
I'll repeat what I said above: "I'd interview both and see which one fits best." It's good to have choices. Your choice likely won't be mine.
I was worked up and treated at MSKCC; so was my younger brother. My dad was worked up there too (though treated locally by a urologist out-patient). I was generally very satisfied with my treatment, and so far my brother and I have not had any evidence of recurrence. Of course, if your dad (like mine) has widely disseminated disease, it is unlikely he will need a surgeon. In any case, it is always helpful for the patient to be accompanied if possible by knowledgeable friends during consultations. There is a lot of rapid-fire information and we always found that everyone there missed part of the information and together we pieced together a more complete story.
This is a very individual thing. While I have no experience with NYC Columbia Pres. with my prostate (just for a broken shoulder with an affiliated orthopod via HSS), it is likely I will need a heart valve repair at some point, and if so I plan on using them.
Agreed. Since it left the prostate maybe the biopsy should come from a lymph node(at least not as uncomfortable) at least this is what the mo did for my husband.
I would start with a 3T MRI before having a biopsy. If a biopsy is needed, make sure it’s done live in a MRI vs. having a trus /blind biopsy. Then a PMSA scan.
I think the PSMA-Pet scan first, then if needed the biopsy. Having the biopsy first will result in injured tissue being looked at in the PSMA-Pet scan. That possibly could change the results.
Get him to Sloan Kettering...... Kimmel Center 68th and First. The best doctor you can see is Dr. Michael Morris, but he's up to eye balls in patients. Ask him for a reference....
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