Study I am qualified for

[Muffin2019]

Not sure which study I am going to be in, uses genetic xtandi and LU177, he is sending me consent forms , he seemed pretty excited. I did show interest since a year and half on abitrone which is starting to fail . I have had two PSA readings where it increased, 1.3 to 4.4 now 5.0. He tried to get a PET psma scan approved through insurance but they denied it, last scan was January 31 of this year that showed no disease progression as did the bone scan with no new lesions. This study would have a PET/PSMA scan then go on generic xtandi with LU177 infusions every 6 weeks. Does it drive the PSA down? The study pays for everything with scans as they require. I do not know yet the studies name but getting consent forms sent to me and should gave them by monday. How bad are the side effects of xtandi generic and LU177? If I stay with the arbitrone he says chemo is out but xtandi is in and I can have chemo down the road with the two meds they use and more options also. I am interested as 4 years ago if I had not done chemo he said I would probably not be here . Need your opinions, if he were me the oncologist would jump at this oppertunity, he has not been wrong yet for treatments. My concern is the side effects from both meds. Does this increase survival time and would radiation down the road still a possibility. Need some opinions and those that have had this to see how they tolerated it and are they better off. Thank you for responding .

[noahware]

I recently started a similar trial after a PSA rise on abi, with randomization to either Xtandi or Lu-177. (My trial stipulates no prior chemo.) I ended up in the Lu-177 arm, with my first treatment a few weeks ago. Other than nausea on the first/second days, no side effects.

Be aware that for about a third of men, the Lu-177 will not do the job. But I was very excited to take the chance! My MO was also very encouraged by the opportunity. Good luck to you, hope you qualify.

[Muffin2019 in reply to noahware]

Thank you, the nausea can be taken care of with pills a.i assume , I am leaning to saying yes due to the cost is not up to me but the study. Did you get a PET/PASMA scan first ? Last sacns we're good, no progression indicated. That could be why the insurance denied the request. A woman's husband died due to covid restrictions on medical scans, it was in his liver. This study just shows a two progression increase in PSA and does not care about the chemo 4 years ago to qualify.

[noahware in reply to Muffin2019]

Yes, my trial required a PSA progression but did not require progression indicated by scans. And a PSMA-PET was then required to make sure the Lu-177 even had a chance to work. Some (maybe 10-20%?) men's PC does not express enough PSMA to qualify.

[Hidden in reply to Muffin2019]

A good indica helps my nausea ! And promote my appetite.

[Tall_Allen]

Why is chemo out?

[Muffin2019 in reply to Tall_Allen]

The abritione will not do the job and already did chemo in 2018, he feels that this will drive down the PSA and take care of the cancer cells if they are giving out the PSAMA. My insurance denied the PET scan. He said if I wait there is limited treatments when the abi totally stops working which more than likely by the end on this year. If I do this there are more options after this treatment down the road if PSA goes up and I can have chemo again. You apparently have limited options after the abritione stops and I took it that you could not take chemo again ? A woman's husband had no indication of progression and never had a PET scan by the VA in Virginia due to covid and he died drin the cancer was in his liver which the Pet scan would have indicated.

[Tall_Allen in reply to Muffin2019]

I think it is a good idea to alternate chemo with advanced hormonal drugs:

prostatecancer.news/2019/12...

[Muffin2019]

Thank you, will look and read before the end of next week, this week has been super busy.

[Hidden]

I’m with his doc! Pull the trigger on that pc! It deserves no less. Side effects be dammed. Put it down . Good luck to you both Muffin! 🥊🥊🙏🎯

[Muffin2019 in reply to Hidden]

I np doubt will do ghe study, damn the side effects.