Low testosterone are associated with the extend of lymphnodal invasion at radical prostatectomy and extended pelvic lymph node dissection

Abstract

Objective: To investigate clinical factors associated to lymphnodal metastasis load in patients who underwent to radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND).

Materials and methods: Between November 2014 and December 2019, ET was measured in 617 consecutive patients not under androgen deprivation therapy who underwent RP and ePLND. Lymphnode invasion (LNI) was codified as not present (N = 0) or with one (N = 1) or more than one metastatic node (N > 1). The risk of multiple pelvic lymph node metastasis (N > 1, mPLNM) was assessed by comparing it to the other two groups (N > 1 vs. N = 0 and N > 1 vs. N = 1). Then, we assessed the association between ET and lymphnode invasion for standard predictors, such as PSA, percentage of biopsy positive cores (BPC), tumor stage greater than 1 (cT > 1) and tumor grade group greater than two (ISUP > 2).

Results: Overall, LNI was detected in 70 patients (11.3%) of whom 39 (6.3%) with N = 1 and 31 (5%) with N > 1. On multivariate analysis, ET was inversely associated with the risk of N > 1 when compared to both N = 0 (odds ratio, OR 0.997; CI 0.994-1; p = 0.027) as well as with N = 1 cases (OR 0.994; 95% CI 0.989-1.000; p = 0.015).

Conclusions: In clinical PCa, the risk of mPLNM was increased by low ET levels. As ET decreased, patients had an increased likelihood of mPLNM. Because of the inverse association between ET and mPLNM, higher ET levels were protective against aggressive disease. The influence of locally advanced PCa with high metastatic load on ET levels needs to be explored by controlled trials.

pubmed.ncbi.nlm.nih.gov/342...

[pjoshea13]

Table 1 in the full text [1] has useful testosterone [T] data.

Note that the modern cutoff for hypogonadism is 350 ng/dL.

By the time men have entered the PCa years, their T has generally declined considerably since age 30. At diagnosis, many men are close to 350 ng/dL, if not well below it.

All [617] men: 432.4 (339.8–535.3)

Number of lymph node mets:

- zero [547]: 433 (340.3–538.9)

- not zero [70]: 416.3 (332.5–493.5)

- only one [39]: 443.8 (363.1–536.6) ..... !!! ??? .....

- more than one [31]: 382.2 (330.6–465)

-Patrick

[1] ncbi.nlm.nih.gov/pmc/articl...

[Hidden]

What is ET?

[pjoshea13 in reply to Hidden]

"Endogenous testosterone" - as measured in the blood.