Prolactin is food for prostate cancer

An MO and an RO both said the same thing. #2 food for PCa.

Cabergoline is very effective to reduce. I started caber over 2 years ago. My prolactin is <1.0 ng/ml (lab min threshold).

ncbi.nlm.nih.gov/labs/pmc/a...

[StayingOptimistic]

What is #1?

[Hidden in reply to StayingOptimistic]

The MO thinks it is testosterone. The urologist thinks that we don't really understand testosterone. Because there are guys like me who do super high testosterone and do very well. I don't know what the RO thinks.

[Jeremiad53 in reply to Hidden]

What do you mean by "do super high levels of Testosterone"? Are you getting medical supplementation?

[Hidden in reply to Jeremiad53]

Higher than 1500 mg/dl. I used cypionate 400 mg/wk. 2000-4000. Now I use Androgel 6 pumps of 1.82% (each pump supplying about 5 g of gel). This gets me to about 1900 but easier to maintain a given level and drop off rapidly (I'm doing a form of BAT).

[StayingOptimistic]

What do you take, in terms of dosage and form please?

[Hidden in reply to StayingOptimistic]

I forgot to add that info.

I take 0.5 mg once a week.

[LearnAll]

Cabergolin certainly lowers prolactin level. But there is a natural substance which can do the same. The name is VITEX FRUIT by Natures Way...available on Amazon in capsule form.

[Hidden in reply to LearnAll]

Do you take it? How much did it drop your prolactin? Bromocryptine also works but is harsher than Cabergoline.

[LearnAll in reply to Hidden]

I did take it last year ..for one month. It dropped prolactin by 35% in a month.

[GeorgeGlass in reply to LearnAll]

LA, Do you take mucuna l-dopa and vitex fruit? Does that prolong the cancer suppression while on a 2nd line AR, like Nubeqa?

[Hidden]

How much did it lower your prolactin? My NMD wanted me to take Cabergoline. I'll follow-up with him but the more info I have the better.

[Scout4answers]

Great discussion. Just the kind of info I want to know. Priceless

[andrew61]

I was patient XY. I'm not entirely convinced the conclusions are correct because I was on multiple treatments at the time. I also don't think I was castrate resistant at the time. That just happened around July this year (2021).Despite that, I've added cabergoline to my new treatments - just in case. Doesn't seem to cause any harm. The same rationale we use for so many things we do unfortunately.

[MateoBeach in reply to andrew61]

Thanks for that report on your case. They are essentially declaring you cured of your PC in the case report. From topical 3% Clioquinol plus 50 mg Zinc, and also Lu177-PSMA treatments “cleared” the androgen sensitive population. Then the cabergoline cleared the androgen independent. Does that fit with your status now? Are your scans completely clear and PSA undetectable off treatment? If so: Extraordinary results!

[andrew61 in reply to MateoBeach]

I was not cured - as far as I know there is no cure! Cancer started to spread around July 2021 including, for first time, to bone (met on C1). I went for more Lu177, this time in Germany. Subsequent PSMA scan showed Lu177 effective against lymph nodes but bone Mets continued to spread. I have started Jevtana plus Cabergoline.

[Spyder54 in reply to andrew61]

Article said “The subsequent PET scan (positron emission tomography) revealed the absence of malignancy; and the CTC (circulating tumor cells) decreased from count=5.4 to count=0.”. This is a quick turn to the negative for you. Sorry Andrew. What prompted the trip to Germany for a 2nd LU-177? It seems there are many trials underway here. I assume more experience?

Does it still run about $25k in Germany, all in w travel expenses?

Thanks,

Mike

[Hidden in reply to andrew61]

Interesting how they "forgot" to mention that you were on other treatments. I hate disinformation. It reminds me of Jane "you know who"'s claim that blocking pathways with her mixture of stuff "cured" her. She seems to ignore the fact that it was likely the surgery, or the chemo, or the radiation treatments that put her cancer in remission.

[CurrentSEO in reply to andrew61]

Hi Andrew,

after you went on to remission and your June 2019 pelvic and prostate radiation , did you take any medications till you cancer returned in July 2021?

Thank you.

[andrew61 in reply to CurrentSEO]

I remained on Lupron and Zytiga.

[TJGuy in reply to andrew61]

So back on Jan 31, 2019 the article is pronouncing you clear of cancer.But you said you became CR in July 2021. So they based their statement on PSA <0.1 and clear scans? But it has returned it seems at some point. How long did you remain in remission? Is it expected this can be repeatedly repeated, are you in the process of repeating it?

What did you experience if anything in terms of side effects.

Can you be on this alone, or must you still be on ADT ? The appears quite low for this perscription.

[andrew61 in reply to TJGuy]

I maintained a low PSA while staying on lupron and zytiga until July 2021 when PSA started to increase rapidly. I am now on Jevtana and Carboplatin. I’ll take cabergoline because I don’t notice any side effects but I’m not hopeful about it. Please don’t put too much faith in that publication.

[ocman]

What brand do you recommend?

[noahware]

What causes higher prolactin?

In other words, aside from taking substances that help reduce prolactin, do we know what foods, drugs, activities, etc. might INCREASE prolaction, such that we could reduce or eliminate them (and thus lower prolactin levels at least relative to higher levels)? Would that even be of potential benefit? (SEEMS like it would be, intuitively.)

[lokibear0803]

Wondering why we haven’t heard more about this. I’m not finding a lot of clinical trials that refer to prolactin or cabergoline…seems like this would be pretty game-changing. Am I misunderstanding something here?

[Hidden in reply to lokibear0803]

There are only a few trials. I don't think it's a game-changer. #2 food (if Kwon is correct). I'm thinking it would be like my minimizing fats (maybe my #2 food after carbs). ADT and prolactin inhibition would be like minimizing fats and carbs. I'd lose weight but I doubt that I would die. Lots of protein, a few carbs, and some fat calories at my disposal. Maybe a lot of alcohol. If I was back in a frat it sounds like it would be fun!

[j-o-h-n]

Should have been named Grolactin for us guys with big knockers.............

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/24/2021 5:13 PM EST - Happy Christ's birthday tomorrow.

[JPOM in reply to j-o-h-n]

We need The Man-Bra! I got a solid c-cup going here; some ex-girlfriends would be jealous

[j-o-h-n in reply to JPOM]

We suffer.....When lying on the beach on my back, I place two baseball caps on my chest.....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/01/2022 6:28 PM EST

[JPOM in reply to j-o-h-n]

i never lie on the beach... always tell the truth.

[j-o-h-n in reply to JPOM]

You got me there............but if I were telling the truth I'd be lying...........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/01/2022 6:59 PM EST

[JPOM]

In case anyone wants to know what the heck prolactin is (I never heard of it before this!), short story is: Prolactin is a protein hormone of the anterior pituitary gland. For more, pubmed.ncbi.nlm.nih.gov/110...

[JPOM]

Oh geez... unless I've read this wrong, disrupting prolactin "pathways" can cause tumor growth... pubmed.ncbi.nlm.nih.gov/292...

[Hidden in reply to JPOM]

The article seems to be mostly concerned with breast cancer. It mentions prostate cancer but this is how it does it: "Evidence for this autocrine role is provided by transgenic mice overexpressing Prl under a prostate-specific promoter (Pb-PRL) that developed prostate hyperplasia in the absence of elevated serum androgen levels [70]."

I don't tend to put a lot of stock in mouse studies but this one seems to be claiming that overexpressed prolactin stimulated the prostate. Hyperplasia is the first step to cancer.

So, apparently, high levels are cancerous for male mice.

[Spyder54]

Russ, another great research piece from you worth saving! Many thanks.If a Man becomes castration resistant, Cabergoline is a must to lower Prolactin. It also sounded like LU-177 helped with PSMA Positive PCa, and Cabergoline cleaned up the rest. AMAZING! SAVED!

Merry Christmas to you and yours,

Mike

[Hidden in reply to Spyder54]

Thanks Mike, Merry Christmas and Happy New Year!

[Spyder54]

Andrew61, are you certain you were patient XY?Your results seem somewhat different than the case in the PubMed article.

Now I see JPOM saying disrupting Prolactin Pathways can cause tumor growth?

Not sure what to make of all this (what seemed like Amazing news).

Staying tuned, paying attention,

Mike

[andrew61 in reply to Spyder54]

I am certain.

[Spyder54 in reply to andrew61]

Thanks Andrew for confirmation u r patient XY. Strange the article says u were Castration Resistant yet u maintain Cast Sensitive. Makes me wonder about Article which seems so promising. Then Mateo Paul points out his study show Cabergoline better if started at ADT Start vs waiting for Cast Resis.

Thank you for speaking up.

Mike

[Hidden in reply to Spyder54]

Perhaps disrupting Prolactin Pathways can cause tumor growth in breast cancer and, according to this article, prostate cancer in mice is started with high prolactin.

But, alas (to humor my wife and womankind), I am not a woman, and (to humor micekind), I am not a mouse.

[MateoBeach]

This is a very important topic to understand. I have learned much from the linked article’s references showing the inter relationship between the loss of the zing transporter ZIP1 in prostate cancer, and then the contributing effects of testosterone and of prolactin in maintaining and progression to testosterone independent CRPC and prolactin dependent then independent PC. The following study explains the whole dilemma. You can skip to page 24 if you find the mechanisms confusing.

ncbi.nlm.nih.gov/labs/pmc/a...?

report=reader

The implications for treatment include adding a ZIP1 independent means for restoring zinc levels that are toxic to PC cells. Clioquinol is a zinc ionophore proposed for this purpose. Clioquinol is available as a 3% topical product (Vioform and others). So applying some amount to skin in some amount or frequency while also supplementing zinc 30-50 mg may have some therapeutic value. However I am not aware of any clinical trials on this and am unclear about Clioquinol bio availability via the skin, or how much to apply. Quercetin also has zinc ionophore activity.

ncbi.nlm.nih.gov/labs/pmc/a...

Then there is the other issue of prolactin also being a regulator of PC progression, especially during androgen ablative treatments, ADT. A good case is made for the possible therapeutic role of Cabergoline to suppress prolactin on the way towards androgen independent PC. What was not clear to me is the timing. The original article posted seems to suggest that prolactin suppression is most important after castrate resistance has occurred. But the mechanisms layer out in the first article above imply that prolactin suppression should be employed as soon as ADT is started as a long-term treatment.

I will also post this in a new thread to collect more thoughts on it. Thank you RISH1.

[Hidden in reply to MateoBeach]

Wow! Your detailed analysis of these research articles is always impressive. Thanks!

[ctflatlander]

How do you test for prolactin? blood test?

[CurrentSEO in reply to ctflatlander]

yes

[Zzzgott]

The label on Mucuna L- Dopa 20%. says promotes maintaining sexual desire and ability, Promotes feeling of enjoyment and motivation. I read into that increased testosterone. Which I think would be contrary to the purpose of ADT?

[Hidden]

Some URLs that I had bookmarked

1. [The Suppression of Prolactin is required for the Treatment of Advanced Prostate Cancer - PMC](ncbi.nlm.nih.gov/labs/pmc/a...

2. [Prolactin, stem cells and prostate cancer | ECE2011 | 13th European Congress of Endocrinology | Endocrine Abstracts](endocrine-abstracts.org/ea/...

3. [The role of prolactin in prostate cancer](medigraphic.com/cgi-bin/new...

4. [Sci-Hub | Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends in Endocrinology & Metabolism, 21(11), 691–698 | 10.1016/j.tem.2010.08.004](sci-hub.se/https://linkingh...

5. [Long-term cardiac (valvulopathy) safety of cabergoline in prolactinoma - PMC](ncbi.nlm.nih.gov/labs/pmc/a...

6. [A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How? - PMC](ncbi.nlm.nih.gov/labs/pmc/a...

7. [Sci-Hub | Prolactin-Induced Prostate Tumorigenesis. Recent Advances in Prolactin Research, 221–242 | 10.1007/978-3-319-12114-7_10](sci-hub.se/https://link.spr...

8. [Prolactin receptor targeting in breast and prostate cancers: New insights into an old challenge - PubMed](pubmed.ncbi.nlm.nih.gov/285...

9. [Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors - PubMed](pubmed.ncbi.nlm.nih.gov/206...

10. [Investigative Clinical Study on Prostate Cancer Part VIII: Prolactin Hormone and the Pituitary-Testicular-Prostate Axis at the Time of Initial Diagnosis and Subsequent Cluster Selection of the Patient Population after Radical Prostatectomy | Anticancer Research](ar.iiarjournals.org/content...

11. [Randomized Pilot Study of Cabergoline, a Dopamine Receptor Agonist: Effects on Body Weight and Glucose Tolerance in Obese Adults - PMC](ncbi.nlm.nih.gov/labs/pmc/a...

12. [Phase I Study of LFA102 in Patients With Advanced Breast Cancer or Castration-resistant Prostate Cancer | Anticancer Research](ar.iiarjournals.org/content...

13. [The Survival Effect of Prolactin on PC3 Prostate Cancer Cells - ScienceDirect](sciencedirect.com/science/a...

14. [Prolactin and cancer: Has the orphan finally found a home? - PMC](ncbi.nlm.nih.gov/labs/pmc/a...

15. [Testosterone, prolactin, and oncogenic regulation of the prostate gland. A new concept: Testosterone-independent malignancy is the development of prolactin-dependent malignancy!](urotoday.com/recent-abstrac...

16. [Possible Involvement of Prolactin in Endocrine-Resistant Metastatic Prostate Cancer](journals.sagepub.com/doi/pd...

17. [The Survival Effect of Prolactin on PC3 Prostate Cancer Cells - ScienceDirect](sciencedirect.com/science/a...

18. [The Role of Prolactin in Men](longdom.org/open-access/the...

19. [Development and Potential Clinical Uses of Human Prolactin Receptor Antagonists | Endocrine Reviews | Oxford Academic](academic.oup.com/edrv/artic...