I am trying to get my head round the science of ADT after castrate resistance. Why do we continue with ADT after it obviously doesn’t have any effect?? Longterm ADT has long term side effects – bones especially.
And if intermittent ADT (100% dose til psa rise) is non inferior to continuous ADT - can we make a version where the ADT standard dose is taken but at double the interval – which means giving a shot of ADT at regular intervals to prevent progression rather than waiting for progression and then going back on a full dose as in IADT. Can this maintain some level of ADT, but not as severe and the T level will remain low?
Does the idea of moderate doses give way to the possibility of a longer time to regression?
Can all you knowledgeable guys out there throw some light on this???