I asked this same question last year, but here it is again.
I’m 51 now, diagnosed at 46 - ADT for the entire time, except for a high-T clinical trial. I’ve run through most SOC and then got lucky and qualified for pembroluzimab. That was my Hail Mary and now I’m basically NED. I was undetectable PSA for almost a year <0.01 then it slowly crept up to 0.19 over the second year. Last PSA was a decline to 0.15. I’ve been on pembro for 2 years now. On my high-T clinical trial, I had a mixed response some pc declined and other areas got worse. I’m MSI-h so a lot of genetic variation in my PC.
Question: If pembro is controlling my PC so effectively what good does ADT do? And at 51 Is it still worth any benefit given impacts that result?