"What You Eat Affects Tumors: Diet May Slow Cancer Growth"

[GeorgeGlass]

I read this article yesterday and thought some of you might like to read it. I also like the website for a variety of science related articles.

Here's the link to the article:

scitechdaily.com/what-you-e...

[GeorgeGlass]

I just noticed someone else posted this article from the MIT website. I'll leave this post just in case people want to check out the scitechdaily website.

[msnik in reply to GeorgeGlass]

Hello George Glass,

I just read the article.

Thank you. I found it interesting.

I think fmenninger hit the nail on the head: .......MICE.....

laughing......

here is an excerpt from the article:

"Although this study showed that calorie restriction has beneficial effects in mice, the researchers say they do not recommend that cancer patients follow a calorie-restricted diet, which is difficult to maintain and can have harmful side effects. However, they believe that cancer cells’ dependence on the availability of unsaturated fatty acids could be exploited to develop drugs that might help slow tumor growth.

One possible therapeutic strategy could be inhibition of the SCD enzyme, which would cut off tumor cells’ ability to produce unsaturated fatty acids.

“The purpose of these studies isn’t necessarily to recommend a diet, but it’s to really understand the underlying biology,” Lien says. “They provide some sense of the mechanisms of how these diets work, and that can lead to rational ideas on how we might mimic those situations for cancer therapy.” "

( MIT postdoc Evan Lien is the lead author of the paper, which was published on October 20, 2021, in Nature.)

Good luck to all of us, and the mice, and the dogs and the researchers.

p.s. to whoever wrote the headline for the article, suggested change: "What Mice Eat Affects Tumors......the science may help humans...."

[GeorgeGlass in reply to msnik]

I don't think it is difficult to eat a calorie restricted diet, as long as you have free time to make the healthy foods and too eat them, because it takes longer to eat healthy, low calorie foods than it is to shovel "non-food" down the gullet from fast fast joints. Most of what people in America eat, is all garbage and has very little nutrition, plus lots of destructive content. That's why 70% of the country is overweight and about 40% are obese. Mankind did not eat like this throughout history, until relatively recently.

Most of the study abstracts tell you not to do certain things without talking to your doctor first. That is code for, "we don't want to be sued and found liable for you following advice from our article, even if we think it's probably good for your health" The entire, "ask your doctor first" talking point is complete bullshit 90% of the time. Whenever I've asked and of my doctors, questions about food and diet, they know NOTHING, Nothing, nothing!!!!. They never study it in college. The only useful answer I ever got was from a pain management acupuncturist at Walter Reed. Her advice has improved my health significantly by changing aspects of my diet. I had the cardiologist cause a dissection in my heart in 2016 during stent emplacements. It was malpractice really. They had some internist step in without telling me and he caused the dissection. I almost died. After the other doctor saved me, I was told to take several heart meds which made me feel AWFUL. The stents didn't help, and actually made things worse. I then changed my diet based on the acupuncturists recommendation. I simultaneously started on crestor. I wanted to start at low dose to see about side effects. They gave me 20mg a day but I took 2.5mg. The diet cut my triglycerides in half but the doctor said, wow, look what the Crestor did. I said, I'm only taking 2.5 mg. The triglycerides were mostly lowered due to diet changes.

I could tell you about five other stories just like this. The doctors never accept that the patient could know more than them. The doctors treat most patients like they are clueless, when it's sometimes the other way around.

The bible talks about the benefits of fasting and fasting has been effective for thousands of years. I'm tired of all these studies saying, "this or that looks promising but more research needs to be done" Well, get moving and do more research. You read these studies from 10 years ago, that "need more research", but then nobody does more research.

They say, "don't do calorie restriction because it can be dangerous" but they don't say, not to eat garbage food, all day everyday, even though that kills people in the billions. It also speeds death from cancer. I don't need a study to tell me that.

One thing that many animals have in common with people is that for thousands of years, we've all had to grow or find food to eat (until modern times in wealthy countries). That inconsistencies causes periods of time without food (unintentional fasting). During that time, weak cells die off and new cells are generated, making the immune system stronger in the process. As long as people don't get carried away and eat too little nutrition and calories, then it is safe and easy to focus on eating as much as they want, but very healthy foods low in calories, with some intermittent fasting thrown in. That even makes chemo and other cancer treatments more effective.

Have a good weekend man. Happy Halloween!

[fmenninger]

If only the mice model replicates humans we would have a cure by now

[fmenninger in reply to fmenninger]

In spite of some differences, canine prostate is the closest match for the human prostate. It is also considered the best model for human prostate cancer, even though there is no implanted prostate cancer model in dogs, and most studies are done on the benign prostate. It is often used for evaluation of various prostate ablative techniques like PDT and thermal therapy. See the following articles in addition to Ofner at al:

J. M. Keller, G. R. Schade, K. Ives, X. Cheng, T. J. Rosol, M. Piert, J. Siddiqui, W. W. Roberts and E. T. Keller, "A novel canine model for prostate cancer," Prostate 73, 952-959 (2013).

C. L. Lai, R. van den Ham, G. van Leenders, J. van der Lugt and E. Teske, "Comparative characterization of the canine normal prostate in intact and castrated animals," Prostate 68, 498-507 (2008).

B. E. LeRoy and N. Northrup, "Prostate cancer in dogs: Comparative and clinical aspects," Vet. J. 180, 149-162 (2009).

S. Aggarwal, R. M. Ricklis, S. A. Williams and S. R. Denmeade, "Comparative study of PSMA expression in the prostate of mouse, dog, monkey, and human," Prostate 66, 903-910 (2006).

S. L. Chowning, R. C. Susil, A. Krieger, G. Fichtinger, L. L. Whitcomb and E. Atalar, "A preliminary analysis and model of prostate injection distributions," Prostate 66, 344-357 (2006).

C. M. Moore, D. Pendse and M. Emberton, "Photodynamic therapy for prostate cancer-a review of current status and future promise," Nat. Clin. Pract. Urol. 6, 18-30 (2009).

[GeorgeGlass in reply to fmenninger]

yep, they need to start testing humans on death row who volunteer, in exchange for money, which they can leave for their families.

[j-o-h-n in reply to GeorgeGlass]

I'll pay to pull the switches............

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 10/30/2021 7:41 PM DST

[j-o-h-n]

They say you are what you eat...................... Meow......

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/29/2021 11:39 PM DST

[GeorgeGlass in reply to j-o-h-n]

lol