5th Xofigo treatment done PSA is at 692.32

[Yorkielover2]

Getting nervous with the rise in PSA. I know this treatment does not effect it but what does it mean? We are not close to any areas where the PSMA PET are available so it will be the same scan as before but what if it shows nothing new? Beginning to feel more going on and boom one day soon really bad news! Seems like a hit or miss treatment plan! Sorry just scared at moment! Husband so positive and just pushes on.

[NotAlwaysSunshine]

Hugs from across the miles. ❤️💙❤️💙

[Magnus1964]

Are you currently on any ADT drugs with the Xofigo?

[Yorkielover2 in reply to Magnus1964]

Just Lupron.Zytiga was stopped month before Xofigo treatment started. Exgeva for bones since diagnosed

[Magnus1964 in reply to Yorkielover2]

Why was zitiga stopped? Would it interfere with the xofigo treatment? When I was on xofigo I don't think I was on any other drugs.

[Yorkielover2 in reply to Magnus1964]

Not sure reason but they stopped it! Wasn’t working PSA at 300 then.

[Magnus1964 in reply to Yorkielover2]

With a PSA of 300 it is no wonder Zytiga was stopped. It had lost it's effectiveness.

[Yorkielover2 in reply to Magnus1964]

Yes we were trying to just inch down the road. My husband wants quality of life so I believe treatments offered from here put are going to be iffy. He has a very positive out look always has. It helps so much.

[Magnus1964 in reply to Yorkielover2]

If he has not been on xtandi, that might be a good next step after xofigo.

[slpdvmmd]

Did see this recently on combining provenge with Xifigo ncbi.nlm.nih.gov/pmc/articl...

[Yorkielover2 in reply to slpdvmmd]

Just had conversation with his Oncologist about his rising PSA. He said it is probably time for Chemotherapy. We have a month then last Xofigo. Any thoughts of which Chemo may be suggested?

[slpdvmmd]

I am not an oncologist but just like you trying to navigate my disease. My one advantage is I am a physician/surgeon (can also be a disadvantage). If he has not had taxanes (docetaxel) then they may play a role. As the link I sent you demonstrated Provenge may work in conjunction with Radium 223/xifigo. Also when you look at the Lutetium-177 literature if bone involvement does not include extensive marrow involvement it can be beneficial with bone metastasis. Wish I could offer more. I wish you well.