What do we know about reduced ADT instead of IADT??

[Stoneartist]

Picking up a point from Karmaji on another post if ADT works so well in repressing cancer - maybe we only require a half dose (Zoladex meant for three months - but taken every 6 months) to keep the PCa in check once it has been repressed?? Does anybody know of any info, theories, examples, trials, or hypotheses regarding this??

[Tall_Allen]

No. Good data that T below 20 is best. No advantage whatever in non-castrate T.

[tango65]

If the patients can keep testosterone below 20 with spaced Lupron or similar injections , it will not make any difference.

It happened to me. After my Lu 177 PSMA treatment in 2016 and negative PSMA PET/CTs , we decided to stop Lupron. My testosterone never recovered above 20 after the initial Lupron injection in 2016. If we had not decided to stop Lupron to see what was going to happen with the PSA, I will have been on unnecessary Lupron injections for the last 5 years.

[spw1 in reply to tango65]

On the other hand, my husband's T recovered and went above the normal T level within less than 2 weeks of his injection finishing. Since then the same injection does not keep his T value below 20 in the third month - it is already at 34 in 2 months of a 3 month Trelstar. His MO is considering giving him a different shot sooner.

[tango65 in reply to spw1]

Everybody has different reactions to these drugs, perhaps he needs monthly injections to keep the T below 20.

[Magnus1964]

I don't know of any studies comparing IADT and reduced ADT. I am not in favor of IADT. If you are suffering from side effect with ADT, prefer reduced ADT.