Enzalutamide to reduce urination issues?

[Horse12888]

My brother tells me he's taking enzalutamide to reduce his nighttime bathroom trips.

I responded:

"I’m surprised to hear this. Enzalutamide is an androgen receptor (AR) blocker, recently developed for prostate cancer recurrences that eventually fail to respond to ADT, which happens universally, generally in 2 – 3 years. You might want to ask your doctor if it will alter the way body your processes testosterone. You seriously don’t want that."

Did I give him good advice?

[Tall_Allen]

They usually give Proscar or Avodart and an alpha-blocker. If that doesn't work, there are several minimally invasive BPH therapies. If that doesn't work, they try invasive procedures (TURP or HoLEP)

[Horse12888 in reply to Tall_Allen]

Thanks. Was I right that enzalutamide would negatively affect his body's absorption of T?

[Tall_Allen in reply to Horse12888]

That's exactly why they are prescribing it for him. They are giving it to him to avoid activating the ARs in his prostate. It is a drastic solution, but it will work.