Biospy results

[Perfetto-Zeynep]

my dads biopsy results are like this:

bone , right iliac wing, tru-cut biopsy

panCK: positive

PSAP: positive

NKX 3.1: positive

Koromogranin: negative

Sinaptofizin: negative

what do these results mean?

He is still taking eligard and xvega. Xtandi worked for 3 months and he took 6 doses of dosetaxel but new metastasises occured

Doctor reccomended fondatione one cdx gen test and zytiga.if zytiga doesn’t work he is going to start on lutesium.

Should we do the gen test ? Any suggestions?

[Tall_Allen]

It means he has normal acinar adenocarcinoma of the prostate. If they have enough tissue, you can ask if they can also stain for FOLH1 (PSMA) which will tell you if Lu-177-PSMA-617 is likely to be effective, and FOXA1, which will tell you if hormone therapies are likely to be effective. The Foundation One test may provide additional clues.

[Perfetto-Zeynep in reply to Tall_Allen]

thank you for comments that are helpfull as always🙏

[MyWifeMyLife in reply to Tall_Allen]

Thanks for the info! This is exactly what I’ve requested from my Doc. He Still hasn’t tested mine. Actually I’ve never had my hormones from adrenal gland & pituitary gland etc-checked. Also, you know when oncologists say, “can’t do a bone biopsy so to speak..they say it’s too risky due to potential of spreading ca”? I honestly believe after researching this for years, that they don’t want to know or treat the root cause. Many Docs out there have this excuse because it would indicate “if it’s really cancer versus arthritis or osteoporosis which look very similar on scans. What is your opinion regarding this? Just curious, thanks!

[MyWifeMyLife in reply to Tall_Allen]

Hi, when my Doc did a typical (very limited) genetic test..I’ve learned since that there are many other genes that need to be tested. I believe the “cure” for cancer in general is found in the specific genetic mutation. And then each patient could be treated accordingly. If they went ahead & tested a slew of more of genes-they would Find the cure for each person.

[afab]

I would follow your doctor's directives. Make sure that you have a good one and that he or she specializes in prostate cancer and is an oncologist. My doctor is a goto oncologist at Kaiser.

dXtandi and Elegard/Lupron have worked for me for 7.4 years keeping my PSA undetectable and scans clear/consistent with previous scans - Bone, CT, and Density - but everyone is different. If/when Xtanda fails, we will try Zytiga and or Doxatel and take new biopsies for possible immune therapy iotuibs. Hang on! PC was a death sentence 10 hears ago; today there's a large menu of treatment option.

[Perfetto-Zeynep in reply to afab]

thank you a lot for your suggestions and encouragemenets🙏