Prolactin and APC

Cabergoline drops it effectively. I take 0.5 mg/wk and my prolactin is < 1 ng/ml.

ncbi.nlm.nih.gov/pmc/articl...

[Hidden]

Is Mucuna L-Dopa 20% available most anywhere? thanks!

[TheTopBanana]

Interesting post! I tried to find studies on this, mainly found this ncbi.nlm.nih.gov/pmc/articl...

May I ask your refences?

Will definitely be looking into this!

[Hidden in reply to TheTopBanana]

Sure. I originally got the idea from Dr. Edward Friedman's book. Then I did a little research. I started caber and more research has come out. The bulk of it confirms that keeping prolactin low is good. While it might not make much difference for some guys I have done a couple of informal "trials" on myself and, at the very least, I lose body fat while on caber.

Apparently, higher prolactin levels might help inhibit carcinogenesis but once we have cancer there is a lot of evidence that prolactin helps it grow. Many things are like that.

URLs I had in the prolactin folder:

Repurposing of Bromocriptine for Cancer Therapy

ncbi.nlm.nih.gov/pmc/articl...

A phase II study of bromocriptine in patients with androgen-independent prostate cancer - PubMed

pubmed.ncbi.nlm.nih.gov/962...

The Survival Effect of Prolactin on PC3 Prostate Cancer Cells - ScienceDirect

sciencedirect.com/science/a...

The Suppression of Prolactin is required for the Treatment of Advanced Prostate Cancer

ncbi.nlm.nih.gov/pmc/articl....

Prolactin and cancer: Has the orphan finally found a home?

ncbi.nlm.nih.gov/pmc/articl...

Testosterone, prolactin, and oncogenic regulation of the prostate gland. A new concept: Testosterone-independent malignancy is the development of prolactin-dependent malignancy!

urotoday.com/recent-abstrac...

A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?

ncbi.nlm.nih.gov/pmc/articl...

The Suppression of Prolactin is required for the Treatment of Advanced Prostate Cancer. - Abstract - Europe PMC

europepmc.org/article/PMC/6...

A Novel Patient Case Report to Show the Successful Termination of Untreatable Androgen-independent Prostate Cancer: Treatment with Cabergoline (Dopamine agonist) - PubMed

pubmed.ncbi.nlm.nih.gov/312...

Possible Involvement of Prolactin in Endocrine-Resistant Metastatic Prostate Cancer

journals.sagepub.com/doi/pd...

The Survival Effect of Prolactin on PC3 Prostate Cancer Cells - ScienceDirect

sciencedirect.com/science/a...

Cabergoline: MedlinePlus Drug Information

medlineplus.gov/druginfo/me...

Treatment with Cabergoline Is Associated with Weight Loss in Patients with Hyperprolactinemia - Korner - 2003 - Obesity Research - Wiley Online Library

onlinelibrary.wiley.com/doi...

Metabolic abnormalities in patients with prolactinoma: response to treatment with cabergoline | Diabetology & Metabolic Syndrome | Full Text

dmsjournal.biomedcentral.co...

Using Cabergoline For Bodybuilding - dcp2.org

dcp2.org/cabergoline-for-sale/

A Novel Patient Case Report to Show the Successful Termination of Untreatable Androgen-independent Prostate Cancer: Treatment with Cabergoline (Dopamine agonist).

ncbi.nlm.nih.gov/pmc/articl...

The Role of Prolactin in Menc

longdom.org/open-access/the...

Prolactin – Man's Friend or Foe? | The Men's Health Clinic

themenshealthclinic.co.uk/p...

Prolactin, stem cells and prostate cancer | ECE2011 | 13th European Congress of Endocrinology | Endocrine Abstracts

endocrine-abstracts.org/ea/...

The role of prolactin in prostate cancer

medigraphic.com/cgi-bin/new...

Sci-Hub | Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends in Endocrinology & Metabolism, 21(11), 691–698 | 10.1016/j.tem.2010.08.004

sci-hub.se/https://linkingh...

[TheTopBanana in reply to Hidden]

Thank you very much!!

[TFBUNDY in reply to Hidden]

I'm impressed....

[MateoBeach in reply to Hidden]

Really trying to find some authentic clinical research on this topic. And finding it absent. Just theories and the one very incomplete case report. Most of these citations that are more clinical are from the same two Costello and Franklin. I’m becoming suspicious of them. (Sorry can’t help but thinking of Abbot and Costello.)Have any of those who use or have used cabergoline, and/or clioquinol / Zn, seen a dramatic change in their PC status from starting that alone with no other concurrent therapy changes?

[Hidden in reply to MateoBeach]

Go to clinicaltrials.gov and also pubmed.ncbi.nlm.nih.gov/

[TheTopBanana]

Do you get Cabergoline on prescription?

[Hidden in reply to TheTopBanana]

Yes. I asked my NMD for it. He read the research and immediately prescribed it.

[Hidden in reply to Hidden]

That's excellent!

[TheTopBanana in reply to Hidden]

Thank you again for this post! Did your doctor screen you before for heart problems? Altough according to this study is seems to be safe, unless it is a high dosage? ncbi.nlm.nih.gov/pmc/articl...

[Hidden in reply to TheTopBanana]

Coincidentally I saw a cardiologist a few months after I started caber (my BP was high and my MO and I were concerned). I found out that it was from zytiga and taking 1/4 dose with food dropped it substantially. I told my MO about it and she's fine with my dose.

I didn't think it had anything to do with caber but will look into it. Thanks!

[Hidden in reply to Hidden]

I understand that you are taking 1/4 dose of zytiga and your BP reduces. How about PSA? Thanks!

[Hidden in reply to Hidden]

My PSA is 0.027. I'm almost 2 and a half years from surgery. When I had surgery, my Mayo doctors "guaranteed" me that my PSA would skyrocket and I would be in pain within 3 months "maximum" (G9, T3b/c, lymph involvement, organs, no distant mets). So far it hasn't happened. My current SOC MO is super happy with my progress and doesn't want to see me unless I want to talk (she thinks I don't have much to worry about and actually talked me out of doing radiation and told me that she "never sees ADT in the future").

Early last year she told me that I could do whatever I wanted with Zytiga (I started the 1/4 dose experiment late last year). I told her about the 1/4 dose of Zytiga with a meal and she was fine with it.

[Hidden in reply to TheTopBanana]

I'm not sure how to interpret cumulative dose. I know what it means but I'm not sure if there is some time cutoff depending on half-life and excretion (a year?).If there isn't any kind of cutoff it looks like I'm within their safety limits for at least 3 years. I'll ask my NMD if he knows. Thanks again!

[16starsky]

Hi Nal;My Husband as you know is Metastatic, will the Macuna L Dopa help him, before I send for any .

Thanks Kim

[pjoshea13]

Looks like Nal is using:

amazon.com/Mucuna-pruriens-...

My product is cheaper but only 15% (I take 2 daily):

swansonvitamins.com/now-foo...

-Patrick

[TheTopBanana in reply to pjoshea13]

I read that L-dopa could increase testosterone? ncbi.nlm.nih.gov/pmc/articl...

[pjoshea13 in reply to TheTopBanana]

The increase is small. L-dopa would not affect castrate men & should not concern men who are not on ADT - IMO.

-Patrick

[dhccpa in reply to pjoshea13]

Should a person take it if they are on ADT?

[pjoshea13 in reply to dhccpa]

I do. -Patrick

[Canton44 in reply to dhccpa]

I do take Cabergoline + ADT

[Hidden]

Interesting. I thought of doing that but wasn't sure if it would decrease prolactin as much as caber. What are your labs?

[tango65]

I wonder why one should take drugs like cabergoline or parlodel, when there is not evidence of an advantage in progression free survival or in overall survival in patients with advanced PC treated with these drugs.

The phase II study did not show any advantage. There is only a case report where there was a positive effect. Case reports are irrelevant to decide if a treatment should be used.

I do not want to criticize, I am just curious why one should take these drugs which may have significant side effects when scientific evidence of benefit is lacking.

[Hidden in reply to tango65]

Did you read each article I posted? I thought that some of them were more positive.

Also, doing something in isolation isn't the same as doing it in conjunction with other therapies. Hormonally, I keep testosterone > 2000, DHT <40, estrogen between 15 and 28, prolactin <3. I don't know if any of the RCTs address this type of program. I haven't seen any but would love to find one.

[Shooter1]

What kind of dose--is it just instructions on bottle?? I need to look into this.

[Shooter1]

Thanks for the response. Help with restless leg would be good. Mine jump when I get tired or try to sleep.

[Spyder54]

Wow ! Mind is blown. NOT an Androgen receptor issue. It is a Prolactin issue. This is a game changer. Androgen Independence is when PCa becomes deadly. This is what primarily kills 30,000 men each year from advanced PCa. Thank you RSH1. Inspirational.

Mike K

[Hidden in reply to Spyder54]

Thanks. The government is running a bunch of RCTs. Some are done.

[MateoBeach]

The is a single case report. One patient. And cabergolone did decrease the prolactin level and they correlated this with a single circulating tumor cell count of zero. ( from over 5). And apparently on this single finding declared that the mCRPC was “terminated”.Where are the scans? Where are the PSAs before and then on follow up after stopping all treatment ? Most importantly where are any other patients?

There are only four references and 3 are of themselves(the author and co-author Franklin). The 4th is the extensive PC review mentioned that did not address prolactin at all.

There seems to be no “there” there.

Anyone else have their PC “terminated” with this? anyone?

[Canton44 in reply to MateoBeach]

I meant he put me on Cabergoline

[Hidden in reply to Canton44]

What is your prolactin now? Before it was 800?

[Canton44 in reply to Hidden]

14

[Hidden in reply to MateoBeach]

I posted a dozen or so links. I was looking last night and there are dozens of new studies in 2020-2021. More than one case study.

[MateoBeach in reply to Hidden]

I’m interested in any quality study, even a small and preliminary one, showing any efficacy of cabergoline in humans with prostate cancer ( not counting poorly documented individual case studies That cannot even get published in a peer reviewed journal). Ineed more than that to to pin hopes and life too. But I certainly welcome any links you have found that I have missed. Thank you for your research. Paul

[Hidden in reply to MateoBeach]

Did you search clinicaltrials.gov? I found some studies on it. RCTs. I itemized for my data but don't save many links anymore (just summary scores).

[kapakahi]

How do you keep testosterone > 2000, DHT <40, estrogen between 15 and 28? Esp. the DHT?

[Hidden in reply to kapakahi]

T: 400 mg cypionate a week. E2: letrozole 2.5 mg a week. Prolactin: 0.5 mg cabergoline a week. DHT: finasteride 5 mg a day and dutasteride 0.5 mg a day.

[j-o-h-n]

Cabergoline? I get the high-test....and usually a fill-up....pump it myself....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/11/2021 3:12 PM DST

[SPEEDYX in reply to j-o-h-n]

Must be an alternative fuel!

[j-o-h-n in reply to SPEEDYX]

Well Well..... I guessed they finally kicked you out of church this morning... Nice to see you again...

You hit the pedal with your right foot. It's a combination Wind, Sun and Water fuel...There's a Windmill, a Solar Panel and a Water Fountain on the roof of my car....and all I do is fill it up with Cabergoline which is air. I also use Cabergoline to blow up my blow up doll. I'm getting great mileage out of her....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/11/2021 3:31 PM DST

[SPEEDYX in reply to j-o-h-n]

Yes it was a good service!!!...Pulling a Dick Van Dyke with your chitty chitty bang bang[a setup for you]...I see your still playing with dolls too!!!

[j-o-h-n in reply to SPEEDYX]

Play? No way it's serious stuff - we are in love ..... yep my shitty shitty bang bang is ready for the new normal.... It's fossil fuel and carbon free.....They will begin to tax the air the car uses.....They call airplanes, airplanes ours autos will be called autoairs.....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/11/2021 5:55 PM DST

[Dropzone]

Nal, what might those numbers be?

[Dropzone]

Thanks, I'm up around 16. Would Mucuna bring my number down that much?

[Dropzone]

Yes, I understand. I got on this prolactin thing a couple of years ago and have talked to my doctors about it. Although they seemed interested I couldn't get a prescription for cabergoline. I tried natural supps like B6, ginseng, SAMe and others, taking them all together, but could only bring my number down a couple of points at best so I gave up on the prolactin angle. Will get back in the game with the Mucuna and see what happens. Thanks for the info brother!