Eggs and APC: sperlingprostatecenter... - Advanced Prostate...
Eggs and APC
I ate one egg a day before dx, now I eat only one a week... choline and serum cholesterol are the links to elevated PCa risk... but the study referenced above suggests an association early in the disease and not post-dx ... nevertheless, I cut back.
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Support for an association between egg consumption and risk of lethal prostate cancer comes from our previous report of a 2-fold increased risk of prostate cancer progression (mainly PSA rise) associated with high egg intake after diagnosis among men initially diagnosed with localized disease (HR comparing extreme quartiles: 2.02; 95% CI: 1.10–3.72; Ptrend: 0.05) (5). Prediagnostic diet was not available in CaPSURE, and it is possible that the increased risk of prostate cancer progression we observed in that study population was a reflection of egg intake prior to diagnosis. Our observation of no association between postdiagnostic egg intake and risk of progression to lethal prostate cancer, as well as the attenuation of the association in the incidence analysis when following men to date of lethal event, suggests egg intake affects risk of lethal prostate cancer early in the natural history of the disease.
Eggs are particularly rich dietary sources of choline and cholesterol, which are highly concentrated in prostate cancer cells, and blood concentrations of both nutrients have been positively associated with risk of advanced prostate cancer (21, 22). Epidemiologic evidence for choline and prostate cancer is limited; however, a nested case–control study reported that men in the highest quartile of plasma choline had a 48% increased risk of prostate cancer compared with men in the lowest quartile (OR: 1.48; 95% CI: 1.07–2.04; ref. 21). Choline is essential for a variety of cell functions involved in cancer growth and progression (23), and malignant prostate cells have greater uptake of choline and overexpress choline kinase compared with normal cells (24–26).
The high cholesterol content of eggs may also explain the observed positive association between eggs and risk of lethal prostate cancer. Cholesterol homeostasis is disrupted in aging and malignant cells, leading to accumulation of cholesterol, which in turn may act as a precursor for androgen production and alter signaling pathways to promote cancer progression (27, 28). However, although inhibition of dietary cholesterol absorption leads to regression of prostate tumors in rodents and dogs (27), dietary cholesterol has only a modest effect on plasma cholesterol in humans and Park and colleagues reported no association between dietary cholesterol and prostate cancer in the Multiethnic Cohort Study (29).
I cut back on my eggs and dairy and processed meat. I'm getting prepared with the diet and waiting for my time machine to be invented.
Andrew Basiago experienced time travel in the sixties so maybe it's not so far-fetched.
We know that Pca thrives in an Acidic environment, and struggles in an Alkaline environment. Eggs (in particular the Yolk of the egg) are also promoters of Arachidonic Acid. sciencedirect.com/science/a...
The egg lady Erin Richman, was never going to be pro-egg (she mostly writes on vegan matters). I posted on her two egg studies 5 years ago. {I had an egg for breakfast, & after 17 years with PCa, it might be bad luck to stop. LOL.}
healthunlocked.com/advanced...
healthunlocked.com/advanced...
healthunlocked.com/advanced...
{For vegans who like what she says, Erin appears as "Van Blarigan EL" in PubMed.}
-Patrick
Statistics are against it being eggs alone.
I wouldn't necessarily stop all egg-eating if I were in your shoes and enjoyed eggs. Before diagnosis, I ate 3, 4, 5, every day, and sometimes much more. Probably wasn't the wisest thing and I've found other foods that I like much better than eggs (for example a dessert made from frozen organic fruit with some whey protein, eat it after a workout, YUM!!!!!).
Probably a coincidence but ever since I started 12+ oz of fruit and 1+ oz whey protein after my workouts they have exploded! I don't push the same weights I did at 20 but I'm not very far off on some of the exercises.
I compromised last October upon Dx with buying (or separating) Egg whites by the quart. The yolk seems to be the acidic portion. “It all works, but nothing works well”.
Good idea. There are also some vegan eggs that supposedly taste like the real thing.
It's the Osterich eggs that are the killers, they take so long to fry too !
What's on the menu for tonight, a nice leaf, but not too many, maybe a teaspoon of green tea, followed by a dollop of malnutrition , sound yummy 🙄😋😝.
Lol! Sorry but I'm not salivating. I average about 4500 calories a day and have been losing fat and gaining muscle at a fairly rapid pace. I suspect that malnutrition isn't something I'm going to be dealing with in the near future.
But I do like tea! ... and coffee... and fruit... and oatmeal... and walnuts and almonds and legumes and.. well, you get the idea. Some days I go over 10,000 calories (my workouts add about 1500 calories to my 3500 BMR and my average of 4500 is a deficit). In contrast, my wife typically eats about 1500. So a week's worth of her calories sometimes goes down my gullet in a day.
Shoot, you got me thinking about food. I don't like to eat this late but now that food is on my mind I won't sleep.
Have a nice fried egg sandwich before you go bed, it's not too late, I hope you sleep well 💤💤💤💤
Thanks. I opted for my favorite standby: oatmeal, protein, sesame seeds and a couple of pounds of frozen fruit.
Egg sandwich sounds tempting but my wife only had 15 eggs in the fridge and didn't even have a full loaf of bread so not much more than a snack.
I eat egg white omelets daily, I avoid the yolks to avoid the choline (just in case) and cholesterol, trying to stay heart healthy since I’m on long term ADT which is not heart friendly.
Ed
Why would you agree to long term ADT? There is another option.
Which is…?
If you are to be on ADT for life I would choose an orchiectomy.
Still requires ADT - Xtandi
Xtandi is WAY easier on most of us than Lupron.
Uh, not really, fatigue, headaches, BP issues, cognitive issues, I’ve been taking it for 6 years now. Lupron + estradiol patch is not too bad.
Ed
I'm glad you're doing well on it! It's hard on most of us. One of my friends is 58 and used to be very active but now his bones won't take any stress.
That’s where estradiol patches help with bone strength, hot flashes etc. And they don’t cause the cardiac issues that estrogen in pill form does since it’s absorbed through the skin not the liver.
I hear you. I did ADT via estrogen patches. No Lupron. T was undetectable.
I'm fine with self medicating. But he wants his doctor on board and many docs are still behind the times (that's one of the reasons that I'm ok with researching, talking to doctors, and ultimately deciding for myself what to do).
I use estradiol patches to help cope with the side effects of ADT, mainly Lupron.
Ed
Well said sir. With a grandfather, father and sister all dying from cancer, it was the eggs after all. I have normal cholesterol, blood sugars and all other bloodwork is normal, (other than PSA and Testosterone),but finally the source of my aggressive prostate cancer was revealed as eggs!
This study does not show that there is a 100% certainty that eggs cause APC. There might be a slightly increased risk of APC or progression with eggs.
I think that a general understanding of statistics might help. statisticshowto.com/statist...
A good overview of relative riskcdc.gov/csels/dsepd/ss1978/....
Choline pet scans are remarkably accurate. Egg yolks, poultry skins and salmon skins major sources. We need some but a regular diet provides plenty.
Whew! I only eat one half an egg every week. Now, the eggs in the study, were they white eggs? brown eggs? cage eggs? open ranch eggs? cracked from the little end or cracked from the big end? I've got Stage IV cancer, gonna eat and drink whatever I want. I ate my nutritionist, she was delicious.
Lol! Good way to deal with an annoying doctor. Was she cracked from the little end or the big end? Did you cage her before you ate her? Brown or white?
Your reply is funnier than the joke.
Thanx for that. I really enjoyed laughing hard for the first time today 😄
Monte111, your not right our friend, I think you should see a different type of Doctor. 😂
Agreed. But Dr. j-o-h-h has retired.
They'd just become more Monte food.
Is there enough water to float your boat, Phil?
I’ve been known to drink it occasionally, floating my boat on it I have definitely done.
But Monte, have you ever boiled one of those Ostrich cracked at either end eggs, the yokes on me 🥚🥚🥚.
I believe they give one wind 🤫
I already have enough wind to power a small boat. Ostrich eggs and beer, now that is one evil wind. Careful after that meal. You might get what you didn't ask for.
I prefer "Welcome to the Thunderdome". That Aussie chick was hot.
It sounds like it was more about being fat, out of shape, and in general having a very unhealthy high fat diet.
Who could those people be? ... wait, 75% of the American public...
Our government gives mixed signals. On the one hand they stress a healthy diet (some of the details are arguable but in general it's better than most of us eat). On the other hand they subsidize corn and therefore make HFCS dirt cheap. HFCS is one of the biggest contributors to diabetes in our society.
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