Any correlation between bone surgery/injury and bone mets?

[tallguy2]

I’ve had one bone met to date, in the L5 vertebrae. It was resolved with IGRT. That area was the subject of two previous back surgeries.

Now I face a third back surgery in March on the same vertebrae.

Has anyone else experienced a bone met where surgery was done on the same bone?

[tallguy2]

Yes, I wonder if there's ever been a research study on this. Could cancer cells gravitate to an area of rapid growth such as a bone that's healing from a break or surgery? If I get a reoccurrence at the L5 vertebrae I will certainly suggest this to my MO!

P.S. Today would have worked...it was 70 here in east TN, probably the same near you.

[PhilipSZacarias]

Hello tall guy, there is very likely inflammation in the area of surgery and this may activate dormant cancer cells. Surgery in general activates dormant cells because of the release of cytokines (IL-6). NSAIDs reduce inflammation and should be considered as soon as possible after surgery. Patients who have had breast surgery and were given ketorolac generally had a longer survival. This paper can be found in pubmed if you search using breast cancer and ketorolac as key words. Cheers, Phil

[tallguy2 in reply to PhilipSZacarias]

Thank you. I will look for the paper.

[Walter_Gould]

I had many bone Mets and they were all where I had bone injuries in past years.

[tallguy2 in reply to Walter_Gould]

Thank you.

[Patrick-Turner in reply to Walter_Gould]

Hi Walter, It interesting to say bone mets appear at places of past bone injuries. But I have had countless bone mets appear in bones which have not been injured. But I did have both knee joints replaced in Feb 2017, and perhaps Pca moved right in soon after because that is where both femurs and tibias have been seriously cut shorter and drilled out for the titanium inserts, so there is big activity by body to try to heal these areas with increased blood supply so maybe my titanium insert arear within bones have extensive Pca, but PsMa scans didn't sow anything because these scans were limited for between top of skull to beneath hip joints of femurs, and did not include knees. Anyway, 6 doses of Lu177 has seemed to get rid of all visceral mets and I sem to have only bone mets, with some new one with very low PsMa expression.

So no more Lu177 could be given. Instead, I qualified to begin with Ra223, which may kill all bone mets without reliance on PsMa expression.

I just had my first dose Ra223 3 days ago. Ra223 naturally targets areas of bone with high calcium traffic at the bone mets, and experts say it will go to very tine bone mets, not just the big ones, but but I don't know what defines the actual sizes involved. Apparently, big mets are maybe marble sized on scans, say 20mm dia, while small might be 0.05mm dia and last time I looked I had pea sized mets. None of these mets cause symptoms of Pca in bones and I've been able to cycle 200km+ per week at good speed on Canberra's non congested roads and sealed off-road cycle paths.

I'm having a rest off bike for a week to do yard work of cleaning up and clipping hedges which puts my weight on legs which stimulates better bone density, despite the last 10 years on ADT.

See my Pca story and Psa graph at

turneraudio.com.au/Patrick-...

I have no idea if Ra223 will work well or if I use up whatever bone marrow reserve I have left after all previous treatments. So far, no side effects from Ra223, but its early days.

Patrick Turner.