Rising PSA but low T

[jersy]

Hello, All. After two years on Zytiga, my PSA is creeping up (but still under 10), doubling about every 4 weeks. At this exponential growth rate it will be about 5000 in a year. However, Doc unconcerned because he says T is low. Is that correct? What would indicate it is time to switch therapies? Rising PSA and T? How can one rise but not the other? Thanks all and Happy New Year.

[Tall_Allen]

It's called "castration resistance" when the PSA rises in spite of low T. Time to move onto a different therapy.

[jersy in reply to Tall_Allen]

Thank you, TA. Frustrated with Doc because this is exactly what I suspected. When I mentioned moving to chemo, he said he likes to “save that for the end.”

[DarkEnergy in reply to jersy]

Interesting, my doc and I chose chemo from the start, after 6 months of ADT+ treatments. Ask your Doc, how many millions of circulating tumor cells are in your blood...

[Tall_Allen in reply to jersy]

Find a new doctor. Any doctor who, after CHAARTED and STAMPEDE, still believes that chemo should be left for the end, is seriously and dangerously out-of-date.

[Shooter1 in reply to jersy]

Save to the end....BAH-HUMBUG..Hit it hard and early. JMHO

[TNCanuck in reply to jersy]

That's very old thinking by your doc. Recent extensive trials indicate efficacy of EARLY chemo. I think you'd be well served by another opinion. Good luck.

[jersy in reply to Tall_Allen]

thank you for validating my suspicion.

[j-o-h-n in reply to jersy]

Next time you see that Doc..... Point "s o m e w h e r e" and tell him "You're saving this for his end"... Then blow him a kiss goodbye..........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 01/01/2021 6:04 PM EST

[Magnus1964]

This does not mean you won't respond well to another ADT drug. It may be time to switch.