After my last meeting with the Professor, he suggested we try "high dose aspirin" in combination with alpelisib if we can access the latter. In the mean time I've started on 500mg a day (Disprin) and follow up with the man on Friday.
Now I know some of us out there will have a chuckle as you read this however given my resistance to previous chemotherapy and numerous radiation treatments I'm a willing guinea pig , also this is not just pie in the sky stuff as I believe there is some substance to the aspirin theory.
The eventual dose I'm not sure of yet and will be contingent on a number of factors, namely any psa effect, tolerability etc. However speaking to some people and some research 200 mg/daily maybe the aim ?
The main reason for the aspirin at high dosage is according to the Professor, the effect on my previously mentioned PIK3ca mutation and hopefully with the addition of the alpelisib we may have some results.
Love to hear your thoughts
John
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Easey
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From what I can see, Alpelisib is a reasonable thing for you to try, especially since it sounds like you are out of SOC options. It has worked with breast cancer with the same mutation and is approved for that use.
Anyone telling you not to do it because of the risk should answer: What is the worst that could happen? Telling you not to do it because it could be "bad" is like warning people in hospice that they might get addicted to morphine.
Thanks Gregg I agree and looking at the genomic summary I have before me states amongst other things " An activating variant in PIK3CA with implications for off- label therapies was detected. "
So going hat in hand to try and acquire alternative drugs not approved for pc is the suggestion, hence the breast cancer drug I guess.
Thank you and hopefully we might have a drug, fingers and toes crossed, that has some worth.
There has been some research done on Alpelisib for breast cancer, but I couldn't find anything for prostate cancer. High dose Asprin could cause some serious side effects and has not been proven to be a treatment for cancer.
Here's a link to an article about FDA approval of Alpelisib for breast cancer. The article has a link to the prescribing information for the drug.
The Proff is a real Professor , head researcher for different trials , one being the Most trial which I'm on. This is for particapants where conventional treatments have failed and they look at gene variants if any any try to match these with targeted drugs, hence alpelisib.
Roche have a similar drug but apparently there not as for coming as the makers of alpelisib.
Now that one got a big laugh from me...I miss the “little buddy” Gillian. Sometimes it feels like our prostate cancer was a “three hour tour“ that turned into the “weather started getting rough and our tiny ship was tossed.....”
You may ask the professor about Ibuprofen --- it has been shown to be more effective
Results: Ibuprofen was significantly more effective against human prostate cancer cells in vitro than the other tested nonprescription NSAIDs. MTT analysis indicated that clinically relevant concentrations of ibuprofen significantly reduced the survival of LNCaP human prostate tumor cells.
Superior effectiveness of ibuprofen compared with other NSAIDs
Thanks, I think the theory is apart from the anti inflammatory effect of the aspirin at high doses it also (according to research) works to negate the effect of the mutation . My tumors also are no longer androgen sensitive which the ibuprofen is said to have efficacy.
Please be careful with the high dose aspirin. I was taking about 2,500 mg day for a couple months. Began very slight urinary bleeding. Ended up with a few trips to the emergency room plus visits to my urologist to resolve blocked uretha from clotting. Prior radiation had left irritated lining of the uretha that began to bleed from the blood thinning effect of high dose aspirin.
If you stay on the aspirin course, please let us know how it works out.
Always glad to learn more from those in our boys club.
I think there was just a confusing choice of words. If you look back at Easey's prior Posts/Replies from almost a year ago, you will see that he indeed has already had numerous conventional treatments.
If you mean proven treatments such as chemo - docetaxel, Cabazitaxel, carboplatin, radiation to the liver twice, lungs X 1, sacrum X1 , Xtandi, immunotherapy, parp inhibitors - then I'm sorry but am I missing something ?
I've had genome sequencing of my tumors and the mutations are not treatment friendly, please read my earlier post. I'm not psma avid so lutetium is out of the equation , so when I have tumors that are doubling inside my liver and lungs fortnightly then I need to pray for just a little luck and do not belittle the research that has gone into this . The drug alpelisib if available to me will be on compassionate grounds . I've tried everything conventional they can throw at me so if you can't be of any constructive assistance don't reply dickhead .
I should have mentioned IP6 can be purchased over the counter. I use allstarhealth.com. They distribute several brands. I have stayed with Nature's Way IP6 powder. I have been using it since summer of 2015.
I'm keen, it could be very helpful judging by what I have just read. I also have a loss in PTEN tumuor suppressor --
Emerging studies indicate that PTEN loss is associated with alterations to cellular interferon responses in the tumour microenvironment — tumours with loss of PTEN are more likely to have an immunosuppressive microenvironment, suggesting that advanced prostate cancers with PTEN loss might be amenable to immune-based therapies.
The report also states that when you have PTEN loss and PIK3CA variant co- existing, this is associated with resistance to ADT..... great !!!
I did ask the question - if I have certain mutations in the genes it seems logical to pull out the blue prints of the DNA and hit the reset button, was my thinking. Didn't get the answer I was hoping for, but definitely worth pursuing.
Progression to CRPC resistance and therapeutic resistance holds significant challenges to patient mortality; understanding the inflammatory signals that drive these processes can lead to effective therapeutic targeting by existing anti-inflammatory agents (as summarized on Table 1). Indeed, a decade ago, the first randomized, double-blind trials were conducted in order to examine the effect of COX2-inhibitors (Dexamethasone and Celecoxib) in prostate cancer patients [152,153]. One such study revealed a significant reduction in COX2 expression in tumor tissue, when compared with the adjacent benign tissue [152]. Of note, a higher expression of proliferation markers was another interesting outcome in these patients. Furthermore, a low dose combination (dexamethasone and celecoxib) therapy has been applied, which yielded significant long-term benefits in CRPC patient [153]. In contrast, combination Celecoxib and hormone therapy yielded no additional benefits [154]. Overall, the administration of low does Celecoxib (400 mg) twice daily for up to one year was not effective in patients starting hormone therapy for high-risk prostate cancer, and it was not recommend [152]. However, combination therapy may have a positive impact on Castration-Resistant Metastatic Prostate Cancer patients.
I once spent over an hour shipping a package from Staples. It was incredibly frustrating because of all the problems they were having, but I managed not to lose it.
Then I saw that button on the counter: "That was Easy". I could feel my hand wanting so badly to push it. There was a fight going on inside. I knew I could have started pushing that button over and over, just to relieve my frustation. But I restrained myself. No, I didn't even press it one time!
That's what they call control.....I have that button and another one I bought online which says"bullshit" "horse shit" and more shit expressions and it lights up. That one runs out of batteries very quickly...
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