Bone thinning

[BrentW]

I was diagnosed with metastatic PCa in 2004, and have since been treated with hormone ablation. I developed exquisite pain in my bum and thighs about two weeks ago, for which I was given an x-ray to examine bone involvement. This revealed that I have bone thinning, even though I am only 60. Has anybody else been through this? Any advice?

[Boywonder56]

So you were dx at 44...damn the luck...as you know adt deprives u of t..wich i believe is vital to a mans bone strrngth ...of course if we listen only to drs. There are no really bad se to adt.....well theres prob 5k men in here who strongly disagree....just wait and the smart ones will tell you wich supplements,treatment,exercise etc...to improve your malady...im not that smart.....b.w

[noahware]

ADT knocks out not only testosterone, but also the estrogen that men produce FROM that testosterone. Estrogen, more than T itself, is essential for good bone health, so your condition is expected and predictable assuming that issue not having been addressed for over 15 years.

Some men take bisphosphonate meds to address this estrogen loss indirectly, but some men simply use low-dose estrogen patches to restore some of what has been lost. There are trials (called PATCH) in the UK using high-dose estrogen as an alternate form of ADT, and it appears men doing that can actually GAIN bone mass with ADT instead of losing it.

As for addressing your specific situation, now that pain is present, I can't advise on the best treatment plan going forward, besides low-dose estrogen. Perhaps others have ideas for you, so far as what to propose to docs.

[pjoshea13 in reply to noahware]

Aside from using estrogens for ADT (estradiol, DES), low-dose estrogen may reverse your issues.

Is estradiol [E2] < 12 pg/mL? Use the lowest vivelle-dot E2 patch. Target E2 should be ~20 pg/mL. More is not better.

I would try this before considering bisphosphonates, etc, which risk necrosis of the jaw.

Best, -Patrick

[LearnAll]

Fully agree with what Patrick said . Low dose E-2 patches have less side effects than Biphosphonates. E-2 patches have the capacity not only to stop bone loss but to increase bone density and strength. Worth discussing low dose E-2 with your doctor.

[Tall_Allen]

That is a very common side effect of hormone ablation. They usually prescribe Zometa or Xgeva to increase bone mineral density, perhaps Vitamin D and calcium too if your levels are too low.

[George71]

Vitamin D3 10,000 daily K2 and calcium will help strengthen bones

[CalBear74]

Long-term solution: read AKM Shamsuddin’s book on IP6 ( 2011). He has a long history of cancer research at the University of Maryland medical school. His book discusses the positive impact of IP6 on bones As well as cancer cells. I have long used IP6 (2015) powder. My primary care physician commented on the health of my bones after a bone scan required periodically by my insurer for osteoporosis. Shamsuddin’s book offers data confirming the positive impact of IP6 on bones. I find the best price on IP6 powder is available from All Starhealth.com. (I am 78 years old, a Gleason 8, and not yet resistant to Lupron which I Started eight years ago at time of diagnosis.)

[j-o-h-n]

I see that you've been on H.U. for 3 months but not here in our lovely room. So Greetings,,, You've come to the right place for info. regarding Pca.

My M.O. just prescibed a meds for me which is:

Denosumab

Common brands: Prolia, Xgeva

Bone health

It can treat osteoporosis and hypercalcemia. It can also treat bone cancer and bone problems in patients who have cancer.

Brands: Prolia and Xgeva

Availability: Prescription needed

Pregnancy: Consult a doctor

Alcohol: No known interactions with light drinking

Drug class: RANKL inhibitor

Check with your doctor(s) and ask their opinion about using this med (I'm on the Prolia one).

Keep posting here for help..... and keep painting.... (nice stuff)....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/04/2020 7:44 PM DST