Successful treatment

[Fight11]

For all you guys that are castrate resistant . What has been your most successful treatment thus far and how long has it lasted? Would love to share with my husbands Oncologist? ❤️🎈🙏🙏🙏

[Gearhead]

1. Many posts on this message board have included links to studies that address your question. Most are fairly easy to understand. For example, see "Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC" by Tango65, which is only about four posts earlier than yours. A little searching will find many other posts pertinent to your question. Be especially alert to posts by Tall_Allen.

2. Be cautious about interpreting anecdotal experiences. Be especially cautious about taking your husband's oncologist's time by telling him/her about specific cases you've heard or read about.

[Hidden]

Here's a link to the post by Tango65 referenced by Gearhead.

healthunlocked.com/advanced...

When selecting treatments, it's better to look at results of trials with many people than to get andecdotal stories. I'm sure his doctor will be familiar with the various clinical trials that have been done on treatments for prostate cancer.

There is also plenty of information already posted without repeating the same thing.

You can search the posts on the various treatments plus many of us have profiles that give our treatment history that you can read.

[GAdrummer]

We have been playing "Whack a PCA" for eleven years. The most important points are that mcrPCA is a complex, mutating beast and doctors like to stick with a treatment longer than it works to string out the time until new treatments are approved. Sometimes the treatments do more damage than the disease. My husband's cancer is limited to nodes only hiding in inaccessible, tight spots which puts him, right off the bat, in a distinct minority of 10%. So his results have a high probability to mean nothing for your husband's case. Genetic testing saves time, energy and money.

But since you asked, Extandi took one year to reach a nadir of 0.1 but was abandoned two years after nadir as the doubling time took off. After genetic testing and failure of four other agents, the medical oncologist pulled his ace out of his hip pocket: with Keytruda the PSA reached undetectable at four months. It came with a price: after six months an adrenal crisis occurred and we discovered that his adrenal and thyroid gland functions had been destroyed. He was given a four month holiday from Keytruda partially because of COVID-19 fears. After a year off and on Keytruda, scans were clear, even the spot on the pancreas was gone. He will continue on Keytruda for eleven more months, God willing. He is 82.

[lewicki in reply to GAdrummer]

Is the Keytruda a trial that he is doing?

[GAdrummer in reply to lewicki]

The medical oncologist didn't say. He had success with it off-label in other cases. The way it was handled (scans before starting Keytruda and one year later) was similar to an earlier clinical trial my husband tried (and failed) at NIH. We never had to pay for the treatment, so it probably was a test case for the company's application for FDA approval in PCA.

[lewicki]

May I ask how much were the treatments and where did you get them? Thanks

[Hotrod65]

I'm scNEPC, all conventional treatment options failed, I had Prostate removed and sent for Genomic sequencing with Foundation medicine, identified me as carrying a Hypermutated pathology HBM, qualified me several clinical trials and experimental use of a checkpoint inhibitor immunotherapy..#50 Infusions of Pembrilizimab and I'm NED complete Remission 6 yrs after a 3-6 month terminal prognosis, yes, Adrenal insufficiency is my only side affect, controlled with low dose Prednisone, that causes its own issues, but bottom line is I'm still here with QOL.

[Fight11 in reply to Hotrod65]

Omg what a blessing !!!🙏🙏🙏❤️

[dockam]

Had PSA @ 840.2, GL7(4+3) or GL8 in all 18 biopsy core samples, Mets to L side ureter lymph nodes - in 01/2015 and started ADT(Lupron/Casodex) and then 2 weeks later the first of 15 Taxotere sessions( CHAARTED said 6 - my MO saved my life and gave me 9 more)

Got to 0.7 at the end of 2015 . 2016 started Metformin/Lipitor and then a PSA nadir of 0.1 for 3 months in Summer 2017.

But, I may be castrate resistant now, been on Abiraterone since 01/2020 and PSA went up to 4.9 from previous month of 4.3 with T <3

Fight on Brothers

Randy