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Advanced Prostate Cancer

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RhoVac vaccine

TheTopBanana profile image
27 Replies

rhovac.com/wp-content/uploa...

rhovac.com/about-us/rhovac/

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Some hospitals in Sweden and Finland and US are doing double-blind test for this “vaccine”, also interestingly the Finnish hospital told my father who likely have mets that he still might be a candidate?

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TheTopBanana profile image
TheTopBanana
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LearnAll profile image
LearnAll

Thanks. This is something we would like to know more about. You are bringing novel and great ideas on this "knowledge forum" which might benefit many.

Have you read the swedish study about cholera vaccine (decoral) and its positive effect on PCa ?

I drank live attenuated cholera vaccine (vaxchora) on Jan01,2020 and my lymphocyte count jumped by 110% within 2 weeks.

TheTopBanana profile image
TheTopBanana in reply toLearnAll

Thank you so much! Such a compliment on a forum of such knowledge. The main target is people with aggressive PC and successful RP/radiaton to prevent any future mets.

My father though (G-9 recurrent, Possible bone mets) could according to this Finnish doctor still be a candidate for getting the vaccine since it could keep the disease in remission. I can keep you all posted if you would like?

Do you mean this article? nature.com/articles/s41467-...

LearnAll profile image
LearnAll in reply toTheTopBanana

Yes. Exactly this one . Decoral ( dead cholera)

vaccine) is not available in USA. Many people go to Canada to get it.

In USA, we have live attenuated one called,Vaxchora which is by prescription

one time use by oral..its a liquid.

TheTopBanana profile image
TheTopBanana in reply toLearnAll

Interesting! Since my father’s recurrence I’ve been of utmost annoyance to every doctor I’ve met (a million questions regarding everything I’ve read). I will definitely ask my fathers Finnish doctor about this, and a Swedish oncologist.

LearnAll profile image
LearnAll in reply toTheTopBanana

My personal view and that of many knowledgeable members of our knowledge forum is that there is no harm in taking cholera vaccine...it may do some good . Its one dose in 2 years.

TheTopBanana profile image
TheTopBanana in reply toLearnAll

It’s definitely worth trying! But did you have to go abroad to get it?

Also: what were your thoughts regarding RhoVac? Intrigued!

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

Starting to read the article now and i will DEFINITLY get my father to get the cholera vaccine!

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

If it doesn’t harm you, why not try it? But will talk to my father’s doctor about it too.

LearnAll profile image
LearnAll in reply toTheTopBanana

No. My primary doctor gave me a prescription of Vaxchora as my new year's gift after I showed her the swedish study article.

About RhoVac, I will have to study more to comment anything...not enough knowledge yet.

TheTopBanana profile image
TheTopBanana in reply toLearnAll

Must if the studies are either happening now or going to happen soon (I think the one in the US is on paus, I know that the Research Hospital KS in Sweden is doing a trial starting August) and according to this study the trial in Germany is happening now di.se/bors/telegram/3105554...

LearnAll profile image
LearnAll in reply toTheTopBanana

I will watch RhoVac development keenly.

TheTopBanana profile image
TheTopBanana in reply toLearnAll

If my father gets if (here’s to hoping!) I will tell you all about that too. So wonderful if it could work for mPC too, perhaps slow the progression of disease. Looking forward to asking questions to the Finnish doctor on Tuesday! He is involved in the Finnish trials.

DAN65251 profile image
DAN65251 in reply toTheTopBanana

I went to Niagara Falls and drove across the border to buy Ducoral over the counter at a Canadian drug store. it cost abour $100 U.S for the rcomended 2 doses. I declared it to the U.S. border agent and had no problem bringing it across the border.

in reply toLearnAll

Our plan was to go to Canada this summer, but now with the Covid19 that is on hold. We will see what the fall brings.

Tall_Allen profile image
Tall_Allen

Immunotherapies/vaccines that work well for other cancers usually fail to have any effect for prostate cancer. Prostate cancer is particularly "good" at dampening immune attacks. I'm hoping that BiTE or CAR-T may have more activity because they are specifically targeted to proteins uniquely expressed by prostate cancer.

TheTopBanana profile image
TheTopBanana in reply toTall_Allen

Interesting! From what I’ve read so far RhoVac seems to be focusing on the protein RhoC.

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

ncbi.nlm.nih.gov/pmc/articl...

I understand that some studies connect it with distal mets and overall survival.

Tall_Allen profile image
Tall_Allen in reply toTheTopBanana

Prostate cancer prevents most vaccines from working - Google Prostvax or Gvax for some particularly disappointing examples. This is not even targeted to prostate cancer - it's not something I would hang hopes on. There are many more promising therapies.

TheTopBanana profile image
TheTopBanana in reply toTall_Allen

Are you talking about the protein or the vaccin? Because the vaccine is only for prostate cancer:

rhovac.com/cision/662F61039...

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

When I google RV001 all the studies are regarding prostate cancer.

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

edisongroup.com/publication...

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

But since the studies are happening now I don’t think there is that much evidence yet! But hopefully later on!

Tall_Allen profile image
Tall_Allen in reply toTheTopBanana

Great- try it! I admit I am jaded, having seen several such therapies prove ineffective in Phase 3 trials after earlier promise.

ascopubs.org/doi/full/10.12...

fiercebiotech.com/biotech/c...

pubmed.ncbi.nlm.nih.gov/282...

in reply toTheTopBanana

Quote from one of your links bluecatdog:

"RhoVac is collaborating with the University of Tübingen"

On a side note, I have noticed that you liked my post regarding the Philips-Electa MR guided RT linac. University of Tübingen and Heidelberg have two such machines, but only Tübingen is currently having an ongoing trial. I know first hand, because it will be my choice of preference if/when I will become recurrent. The point I would like to make here is that Tübingen is very active in novel PCa treatments.

GreenStreet profile image
GreenStreet

Thanks very much for this. Interesting that it is also recruiting in UK so will check out. I had the Cholera vaccine in early Feb had to pretend I was travelling to India (still credible before Covid 19 really kicked off in Europe!) no side effects but not sure it has materially slowed down PSA progression but I will probably aim to visit India again in 2 years time because it is worth a go imo. Good to see that so much is happening in this area. In longer term I am optimistic about vaccines for PC having gone to a talk from Prof Helen McCarthy of Belfast University but we need something quickly.

ck722 profile image
ck722

I had the cholera vaccine about 45 years ago, Navy. Time for an update.

tasmanien13 profile image
tasmanien13

Hello, hej! In Sweden you are able to walk into a vaccination reception and declare that you are going abroad in order to buy Ducoral. I think almost every city have them located "downtown". Good luck! Hälsningar

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