CANCER VACCINE

[ROLNCIN1]

My husband saw his Oncol. last Fri. for his monthly treatment.

She mentioned that UCSF is doing a clinical trial for a cancer vaccine I think called Sipuleucel-T .

This vaccine is for all cancers. She referred us to UCSF so are waiting to see if he is accepted.

Question: Is anyone familiar with this trial?

Thanks in advance!

BOOGEE

[abmicro]

UCSF is on top of clinical trials with Dr Eric Small. I met with somebody in his group but did not qualify for any trials at that moment. Sipuleucel-T sounds like PROVENGE. If it is, Provenge is already approved and you can get it right now without the rigors of a trial. The only way anybody would do a trial of PROVENGE is if no insurance and need a trial to cover the costs.

[Ahk1 in reply to abmicro]

Yes, it is PROVENGE.

[Ahk1 in reply to abmicro]

I was going to apply for this but the trail says psa has to be greater than .8. When was it approved please?

[abmicro]

Actually, I did a search and found UCSF is running a combo trial of Provenge (Sipuleucel-T) with CTLA-4. I could be wrong, but I heard that CTLA-4 as a single use therapy failed the trials for Prostate Cancer. Combination of 2 immune therapies CTLA4 and PROVENGE is very new and cutting edge. I read that combination immune therapies may work much better than single use therapy, and get good results without the severe side effects of traditional Chemo. I would absolutely look into it. UCSF is one of the best.

[Tall_Allen in reply to abmicro]

A recent test of a combo of checkpoint inhibitors (CHECKMATE 650) had disappointing results and extremely high toxicity. Maybe this combo will do better.

[Crabcrushe in reply to Tall_Allen]

I just realized Yervoy isn't an option for MCRPCa.

Otherwise, I'd consider topping off this Provenge session with ipimilumab while I'm still sportin' a Groshong.

Crabcrusher

[j-o-h-n in reply to Crabcrushe]

Groshong? That's a new one, will add it to my list just after Pee Pee. Thanks...

Good luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/12/2019 7:09 PM DST

[ROLNCIN1]

Thanks all for the replys.

As I understand, it is not Provenge, perhaps similar to.

It also isn't Dr. Eric Small.

I believe it is a Dr. Fong at UCSF who is heading this trial.

It also isn't only for PCA but for all cancers.

Is this getting any closer? I think it's new cutting edge and she (Oncol.) was very positive about this Vaccination. She mentioned it's only blood draw and can be kept for future use.

BOOGEE

[ctarleton]

Here's UCSF's current list of currently recruiting Clinical Trials for prostate cancer, associated with Dr. Fong.

clinicaltrials.ucsf.edu/?q=...

Charles

[ROLNCIN1]

Thanks Charles, will check it out in a bit

BOOGEE

[j-o-h-n]

Vac-cine.... vacate the scene... Is it a day late and a dollar short for us 😆

Good luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/12/2019 7:14 PM DST

[ROLNCIN1]

Bill I sure hope it comes soon for all of us.

BOOGEE

[j-o-h-n]

I love humor but I'm a pessimist.... Last and only time I found a needle in a haystack was in my youth when it stuck her in the ass. What a time .... ho hum... (p left off intentionally).

Good luck, Good Health and Good Humor.

j-o-h-n Tuesday 03/12/2019 7:31 PM DST

[Fuzzman77]

I am on a triple blockade therapy for the time being. I am on Xtandi, Keytruda, and APCEDEN true autologous dendritic cell vaccines. Xtandi about a year, Keytruda for 8 months, and 2 years of on and off of the vaccines. The vaccines melted about 30 tumors in 2 months all that were up into my cheekbone, spine, and sacrum in addition to lymph nodes up to my neck. When I am the combo I am fine. I am at 18 months of stable disease with just my prostate still showing hot on the PSMA PET scans. Take one away and things start going wacky. As long as I am on the combo the last tumor continues to shrink and is about a third the size from when August, 2014 when I was diagnosed with metastatic prostate cancer with a PSA of 212, and Gleason of 9. Just waiting for the other shoe to drop, and hoping it won't.

[ROLNCIN1]

Hi Fuzzman,

Hoping you continue to do well on these treatments.

My husband has been on some form of continueous therapy since 2011 after a RP.

BOOGEE