Frailty, G-8 Score & PCa outcome.

[pjoshea13]

New paper below.

Is frailty inevitable? We could work-out each day & eat a pescatorian diet (aka pesco-vegetarian) like Jack LaLanne & die at age 96 (he died of pneumonia because he wouldn't see a doctor - it would have interfered with his work-out.)

The G-8 {Geriatric 8 score} questionaire [1] allows one to come up with a frailty score.

The new study looked at the G-8 score as a possible prognostic factor.

From a patient perspective, what is the point of something like the G-8 score if it doesn't lead to a change of lifestyle. It's a wake-up call. Treatment-decline can be countered, IMO. {Maybe I'll start tomorrow.}

"The median age was 75 years. Geriatric 8 scores ≤14 were seen in 36% of robot-assisted radical prostatectomy (n = 78/214), 57% of radiotherapy (n = 119/209), 91% of androgen deprivation therapy alone (n = 19/21) and 70% of metastatic diseases (n = 67/96). The median Geriatric 8 score in patients treated with robot-assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone and metastatic diseases was 15.0, 14.0, 12.0 and 12.8, respectively. The median Geriatric 8 score was significantly higher in the metastatic disease than that in localized disease (14.5 vs 12.8, respectively). Robot-assisted radical prostatectomy patients had a significantly higher Geriatric 8 score than radiotherapy patients, with the cut-off value of <14.5. The overall survival was significantly different between Geriatric 8 scores ≤13 and >13 in metastatic hormone-naïve prostate cancer patients, and between Geriatric 8 scores ≤12 and >12 in castration-resistant prostate cancer patients."

-Patrick

[1] siog.org/files/public/g8_en...

[2] pubmed.ncbi.nlm.nih.gov/325...

[Graham49]

Patrick

The G8 score doesn't seem very smart IMO, in that an obese person scores higher than a person with a healthy BMI, other things being equal. Also the score for an obese person would be reduced if weight was lost in the last 3 months.

[j-o-h-n]

Jack Lalanne died when his heart stopped...........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 06/06/2020 11:21 AM DST

[Hidden]

evidencio.com/models/show/1045

My take-away from this topic of discussion? Better go out and do those things you want to do while you are still capable. Biking, hiking, golfing, camping, whatever. You might have the geriatric blues sooner than you expect. It's all downhill fast from there.

[Hidden in reply to Hidden]

Like a giant snow ball !👏🏼