New paper below.
Is frailty inevitable? We could work-out each day & eat a pescatorian diet (aka pesco-vegetarian) like Jack LaLanne & die at age 96 (he died of pneumonia because he wouldn't see a doctor - it would have interfered with his work-out.)
The G-8 {Geriatric 8 score} questionaire [1] allows one to come up with a frailty score.
The new study looked at the G-8 score as a possible prognostic factor.
From a patient perspective, what is the point of something like the G-8 score if it doesn't lead to a change of lifestyle. It's a wake-up call. Treatment-decline can be countered, IMO. {Maybe I'll start tomorrow.}
"The median age was 75 years. Geriatric 8 scores ≤14 were seen in 36% of robot-assisted radical prostatectomy (n = 78/214), 57% of radiotherapy (n = 119/209), 91% of androgen deprivation therapy alone (n = 19/21) and 70% of metastatic diseases (n = 67/96). The median Geriatric 8 score in patients treated with robot-assisted radical prostatectomy, radiotherapy, androgen deprivation therapy alone and metastatic diseases was 15.0, 14.0, 12.0 and 12.8, respectively. The median Geriatric 8 score was significantly higher in the metastatic disease than that in localized disease (14.5 vs 12.8, respectively). Robot-assisted radical prostatectomy patients had a significantly higher Geriatric 8 score than radiotherapy patients, with the cut-off value of <14.5. The overall survival was significantly different between Geriatric 8 scores ≤13 and >13 in metastatic hormone-naïve prostate cancer patients, and between Geriatric 8 scores ≤12 and >12 in castration-resistant prostate cancer patients."
-Patrick
Clarity Update: Complete response in first patient ever treated with 2 doses of Cu-67 SAR-bisPSMA at 8GBq
I’m interested to understand the dna mutations in other brothers metastatic PCa? I’ll start:
